Atherosclerosis in patients infected with HIV is influenced by a mutant monocyte chemoattractant protein-1 allele

Patients infected with HIV present with premature atherosclerosis, and the 2 diseases share common pathogenic pathways. We investigated mutations in the monocyte chemoattractant protein-1 (MCP-1) and CCR-2 genes, which are known to control aspects of these pathways, to ascertain whether they are inv...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2004-10, Vol.110 (15), p.2204-2209
Main Authors: ALONSO-VILLAVERDE, Carlos, COLL, Blai, PARRA, Sandra, MONTERO, Manuel, CALVO, Nahum, TOUS, Monica, JOVEN, Jorge, MASANA, Lluis
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Aged
Alleles
Arteriosclerosis - blood
Arteriosclerosis - complications
Arteriosclerosis - epidemiology
Arteriosclerosis - genetics
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
C-Reactive Protein - analysis
Cardiology. Vascular system
Cardiovascular system
Carotid Artery Diseases - blood
Carotid Artery Diseases - complications
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - epidemiology
Carotid Artery Diseases - genetics
Case-Control Studies
Chemokine CCL2 - blood
Chemokine CCL2 - genetics
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
DNA Mutational Analysis
Female
Femoral Artery - diagnostic imaging
Genetic Predisposition to Disease
HIV Infections - blood
HIV Infections - complications
HIV Infections - epidemiology
Human immunodeficiency virus
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Polymorphism, Genetic
Promoter Regions, Genetic - genetics
Receptors, CCR2
Receptors, Chemokine - genetics
Risk Factors
Tunica Intima - diagnostic imaging
Tunica Media - diagnostic imaging
Ultrasonography
Vasodilator agents. Cerebral vasodilators
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Summary:Patients infected with HIV present with premature atherosclerosis, and the 2 diseases share common pathogenic pathways. We investigated mutations in the monocyte chemoattractant protein-1 (MCP-1) and CCR-2 genes, which are known to control aspects of these pathways, to ascertain whether they are involved in atherogenesis in these patients. We performed carotid and femoral artery ultrasonography to detect subclinical atherosclerosis in patients infected with HIV (n=183). MCP-1-2518G and CCR-2 64I polymorphisms were determined in the HIV group and in a population-based control group (n=348). We also determined MCP-1 circulating levels in the HIV group. The presence of MCP-1-2518G in the group of patients with subclinical atherosclerosis was significantly higher than in patients without atherosclerotic lesions (47.5% versus 18.2%, respectively; P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000143835.95029.7D