Waldenström's macroglobulinemia developing in a patient with multiple sclerosis: coincidence or association?

Multiple sclerosis (MS) has been reported in association with haematological abnormalities, including monoclonal gammopathies. We present a 54-year-old male patient with a 30-year history of MS who was admitted to our hospital for investigation of anaemia and increased erythrocyte sedimentation rate...

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Bibliographic Details
Published in:Multiple sclerosis 2004-10, Vol.10 (5), p.598-600
Main Authors: Deftereos, S, Farmakis, D, Papadogianni, A, Besleme, B, Diamanti-Kandarakis, E, Polymeropoylos, E, Georgonikou, D, Aessopos, A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone Marrow - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Humans
Immunoglobulin M - blood
Immunomodulators
Male
Medical sciences
Middle Aged
Multiple Sclerosis - complications
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Pharmacology. Drug treatments
Waldenstrom Macroglobulinemia - complications
Waldenstrom Macroglobulinemia - pathology
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Summary:Multiple sclerosis (MS) has been reported in association with haematological abnormalities, including monoclonal gammopathies. We present a 54-year-old male patient with a 30-year history of MS who was admitted to our hospital for investigation of anaemia and increased erythrocyte sedimentation rate. A monoclonal IgM protein was detected by serum protein immunofixation, while bone marrow biopsy indicated a 70% infiltration by small lymphoplasmacytoid cells, in the context of a lymphoplasmacytoid immunocytoma, findings compatible to the diagnosis of Waldenström's macroglobulinemia (WM). To our knowledge, this is the first report of WM in a patient with MS. Further to the coexistence of the two diseases observed in the case presented here, there is additional evidence suggesting that the association of MS with plasma cell dyscrasias may not be coincidental.
ISSN:1352-4585
1477-0970
DOI:10.1191/1352458504ms1091cr