Modified DNA Analogues That Sense Light Exposure with Color Changes

We report the discovery of a new class of light-sensing molecules. These light sensors are composed of fluorophore oligomers assembled on a DNA backbone. A combinatorial library of tetrafluorophores consisting of over 14 000 compounds was synthesized and screened for rapid responses toward light exp...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2004-10, Vol.126 (40), p.12748-12749
Main Authors: Gao, Jianmin, Watanabe, Soichiro, Kool, Eric T
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biosensors
Biotechnology
Combinatorial Chemistry Techniques
Deoxyribonucleosides - chemical synthesis
Deoxyribonucleosides - chemistry
DNA - chemistry
DNA - radiation effects
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fundamental and applied biological sciences. Psychology
Glycosides - chemistry
Light
Methods. Procedures. Technologies
Oligonucleotides - chemical synthesis
Oligonucleotides - chemistry
Oligonucleotides - radiation effects
Photochemistry
Spectrometry, Fluorescence - methods
Various methods and equipments
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Summary:We report the discovery of a new class of light-sensing molecules. These light sensors are composed of fluorophore oligomers assembled on a DNA backbone. A combinatorial library of tetrafluorophores consisting of over 14 000 compounds was synthesized and screened for rapid responses toward light exposure. Among the most light-sensitive molecules, at least three tetramers were found to respond to light exposure with apparent color changes, rather than simple photobleaching.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja046910o