A novel and simple strategy for selective and sensitive determination of dopamine based on the boron-doped carbon nanotubes modified electrode

The Boron-doped carbon nanotubes (BCNTs) modified glassy carbon (GC) electrode was obtained simply and used for highly selective and sensitive determination of dopamine (DA). Comparing with the bare GC and CNTs/GC electrodes, the BCNTs have higher catalytic activity toward the oxidation of DA and as...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2009-03, Vol.24 (7), p.2091-2094
Main Authors: Deng, Chunyan, Chen, Jinhua, Wang, Mengdong, Xiao, Chunhui, Nie, Zhou, Yao, Shouzhuo
Format: Article
Language:English
Subjects:
Ascorbic acid (AA)
Biological and medical sciences
Biosensing Techniques - instrumentation
Biotechnology
Boron - chemistry
Boron-doped carbon nanotubes (BCNTs)
Differential pulse voltammetry (DPV)
Dopamine (DA)
Dopamine - analysis
Dopamine - chemistry
Electrochemistry - instrumentation
Electrodes
Equipment Design
Equipment Failure Analysis
Fundamental and applied biological sciences. Psychology
Nanotechnology - instrumentation
Nanotubes, Carbon - chemistry
Nanotubes, Carbon - ultrastructure
Reproducibility of Results
Sensitivity and Specificity
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Summary:The Boron-doped carbon nanotubes (BCNTs) modified glassy carbon (GC) electrode was obtained simply and used for highly selective and sensitive determination of dopamine (DA). Comparing with the bare GC and CNTs/GC electrodes, the BCNTs have higher catalytic activity toward the oxidation of DA and ascorbic acid (AA). Moreover, the voltammetric peaks of AA and DA were separated enough (ca. 238mV) at the BCNTs/GC electrode, which is superior to that at the CNTs/GC electrode (ca. 122mV). Thus, the selective determination of DA was carried out successfully in the presence of AA. A wide concentration range (2.0×10−8–7.5×10−5M) and low detection limit (1.4nM, S/N=3) for the DA detection were obtained. The possibility of the BCNTs/GC electrode for the determination of DA in human blood serum has also been evaluated. The advantageous properties of this electrode for the DA determination lie in its excellent catalytic activity, selectivity and simplicity. The more edge plane sites presented on the BCNTs surface were partially responsible for its good analytical behavior.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2008.10.022