Appearance of skin lesions in cattle populations vaccinated against lumpy skin disease: Statutory challenge

Abstract The ultimate goal of a vaccine is to protect vaccinated animals against re-exposure to the same pathogen and provide sterile immunity. However, a cutaneous clinical manifestation appeared, following re-exposure of cattle that had been vaccinated with the RM65 strain, to LSDV infection durin...

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Bibliographic Details
Published in:Vaccine 2009-03, Vol.27 (10), p.1500-1503
Main Authors: Brenner, J, Bellaiche, M, Gross, E, Elad, D, Oved, Z, Haimovitz, M, Wasserman, A, Friedgut, O, Stram, Y, Bumbarov, V, Yadin, H
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animal populations
Animals
Applied microbiology
Beef
Beef cattle
Biological and medical sciences
Cattle
Disease
Drug dosages
Factory farming
Female
Fundamental and applied biological sciences. Psychology
Genome, Viral
Genomes
Infections
Israel
Laboratories
Lumpy skin disease
Lumpy Skin Disease - immunology
Lumpy Skin Disease - prevention & control
Lumpy Skin Disease - virology
Lumpy skin disease virus - genetics
Lumpy skin disease virus - immunology
Lumpy skin disease virus - isolation & purification
Male
Microbiology
Re-exposure
Sheep
Skin - immunology
Skin - virology
Skin diseases
Vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Attenuated - adverse effects
Veterinary medicine
Viral Vaccines - adverse effects
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Summary:Abstract The ultimate goal of a vaccine is to protect vaccinated animals against re-exposure to the same pathogen and provide sterile immunity. However, a cutaneous clinical manifestation appeared, following re-exposure of cattle that had been vaccinated with the RM65 strain, to LSDV infection during an epidemic in 2006–2007. Four thousand six hundred and seven vaccinated cows entered the study after being re-exposed to LSDV infection. Of them, 513 (11%) presented lumps, and there was a marked difference between the proportions of dairy and feedlot animals that were affected: 146 out of 3517 and 367 out of 1090 (6.6 and 33.7%, respectively). This data suggests that the potency of the vaccine need to be re-assessed for beef cattle.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.01.020