Granulocytic sarcoma presenting with severe adenopathy (cervical lymph nodes, tonsils, and adenoids) in a child with juvenile myelomonocytic leukemia and successful treatment with allogeneic bone marrow transplantation

The occurrence of adenopathy in patients with myelodysplastic syndrome-associated extramedullary myeloid cell tumors has rarely been reported. We describe a 7-year-old girl with juvenile myelomonocytic leukemia who showed the novel chromosomal abnormality t(9;12)(p22;q24.1) and who developed severe...

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Bibliographic Details
Published in:International journal of hematology 2004-08, Vol.80 (2), p.186-189
Main Authors: IMAMURA, Toshihiko, MATSUO, Satoshi, HIBI, Shigeyoshi, IMASHUKU, Shinsaku, YOSHIHARA, Takao, CHIYONOBU, Tomohiro, MORI, Kanako, ISHIDA, Hiroyuki, NISHIMURA, Yasutaka, KASUBUCHI, Yasuo, NAYA, Mayumi, MORIMOTO, Akira
Format: Article
Language:English
Subjects:
Adenoids - pathology
Biological and medical sciences
Bone Marrow Transplantation - methods
Child
Female
Hematologic and hematopoietic diseases
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymph Nodes - pathology
Medical sciences
Palatine Tonsil - pathology
Radiography
Sarcoma, Myeloid - diagnosis
Sarcoma, Myeloid - diagnostic imaging
Sarcoma, Myeloid - pathology
Sarcoma, Myeloid - surgery
Treatment Outcome
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Summary:The occurrence of adenopathy in patients with myelodysplastic syndrome-associated extramedullary myeloid cell tumors has rarely been reported. We describe a 7-year-old girl with juvenile myelomonocytic leukemia who showed the novel chromosomal abnormality t(9;12)(p22;q24.1) and who developed severe adenopathy of the cervical lymph nodes, tonsils, and adenoids that was manifested as granulocytic sarcoma. Following chemotherapy, the patient underwent a conditioning regimen of busulfan, cyclophosphamide, and total body irradiation followed by successful allogeneic bone marrow transplantation from her single HLA locus-mismatched mother at 6 months after her diagnosis. The patient continues to be well and in remission 3 years after stem cell transplantation.
ISSN:0925-5710
1865-3774
DOI:10.1532/IJH97.04040