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Spectral analysis of intracardiac electrograms during induced and spontaneous ventricular fibrillation in humans
Aims Very limited data are available on the differences between spontaneous and induced episodes of ventricular fibrillation (VF) in humans. The aim of the study was to compare the spectral characteristics of the electrical signal recorded by an implantable cardioverter defibrillator (ICD) during bo...
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Published in: | Europace (London, England) England), 2009-03, Vol.11 (3), p.328-331 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Request full text |
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Summary: | Aims
Very limited data are available on the differences between spontaneous and induced episodes of ventricular fibrillation (VF) in humans. The aim of the study was to compare the spectral characteristics of the electrical signal recorded by an implantable cardioverter defibrillator (ICD) during both types of episodes.
Methods and results
Thirteen ICD patients with at least one spontaneous and one induced VF recorded by the device were included in the study. A spectral representation was obtained for the first 3 s of the intracardiac unipolar electrogram during VF. The dominant frequency (f
d), the peak power at f
d, an organization index (OI), a bandwidth measurement, and an estimate of the correlation with a sinusoidal wave (leakage) were estimated for each episode. The f
d was higher in induced episodes (4.75 ± 0.57 vs. 3.95 ± 0.59 Hz for the spontaneous episodes, P = 0.002), as well as the degree of organization assessed by the OI, bandwidth, and leakage parameters.
Conclusion
Clinical and induced VF episodes in humans have different spectral characteristics. Changes in the electrophysiological substrate or in the location of the arrhythmia wavefront at onset could play a role to explain the observed differences. |
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ISSN: | 1099-5129 1532-2092 |
DOI: | 10.1093/europace/eun366 |