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G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response

Innate immunity is an ancient defense system used by both vertebrates and invertebrates. Previously characterized innate immune responses in plants and animals are triggered by detection of pathogens using specific receptors, which typically use a leucine-rich repeat (LRR) domain to bind molecular p...

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Published in:Proceedings of the National Academy of Sciences - PNAS 2009-02, Vol.106 (8), p.2782-2787
Main Authors: Powell, Jennifer R, Kim, Dennis H, Ausubel, Frederick M
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creator Powell, Jennifer R
Kim, Dennis H
Ausubel, Frederick M
description Innate immunity is an ancient defense system used by both vertebrates and invertebrates. Previously characterized innate immune responses in plants and animals are triggered by detection of pathogens using specific receptors, which typically use a leucine-rich repeat (LRR) domain to bind molecular patterns associated with infection. The nematode Caenorhabditis elegans uses defense pathways conserved with vertebrates; however, the mechanism by which C. elegans detects pathogens is unknown. We screened all LRR-containing transmembrane receptors in C. elegans and identified the G protein-coupled receptor FSHR-1 as an important component of the C. elegans immune response to Gram-negative and Gram-positive bacterial pathogens. FSHR-1 acts in the C. elegans intestine, the primary site of exposure to ingested pathogens. FSHR-1 signals in parallel to the known p38 MAPK pathway but converges to regulate the transcriptional induction of an overlapping but nonidentical set of antimicrobial effectors. FSHR-1 may act generally to boost the nematode immune response, or it may function as a pathogen receptor.
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subjects Animals
Biological Sciences
Caenorhabditis elegans
Caenorhabditis elegans - immunology
Gene expression regulation
Genes
Gram-Negative Bacteria - immunology
Gram-Positive Bacteria - immunology
Immune system
Immunity
Immunity, Innate - physiology
Infections
Innate immunity
Insulin - physiology
Intestines
Intestines - physiology
Nematoda
Nematodes
p38 Mitogen-Activated Protein Kinases - physiology
Pathogens
Phenotypes
Proteins
Receptors
Receptors, G-Protein-Coupled - physiology
Worms
title G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response
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