Somatostatin signal transduction in thyroid parafollicular C cells

The effects of somatostatin (SRIF) through its receptors (SSTRs) has been explored in many tissues, and here we discuss the role of the SRIF-SSTR system in human parafollicular C cells, reporting recent data on the effects of selective SSTR agonists on parafollicular C cells, that suggest new therap...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2004, Vol.27 (6 Suppl), p.168-170
Main Authors: Zatelli, M C, degli Uberti, E C
Format: Article
Language:English
Subjects:
Animals
Humans
Receptors, Somatostatin - agonists
Receptors, Somatostatin - antagonists & inhibitors
Receptors, Somatostatin - physiology
Signal Transduction - drug effects
Signal Transduction - physiology
Somatostatin - pharmacology
Somatostatin - physiology
Thyroid Gland - cytology
Thyroid Gland - drug effects
Thyroid Gland - physiology
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Summary:The effects of somatostatin (SRIF) through its receptors (SSTRs) has been explored in many tissues, and here we discuss the role of the SRIF-SSTR system in human parafollicular C cells, reporting recent data on the effects of selective SSTR agonists on parafollicular C cells, that suggest new therapeutic approaches for medical treatment of medullary thyroid carcinoma. Moreover, the possible pathways involved in SRIF signalling in parafollicular C cells are discussed.
ISSN:0391-4097