Neonatal alloimmune thrombocytopenia in Norway: poor detection rate with nonscreening versus a general screening programme

The implementation of an antenatal screening programme for neonatal alloimmune thrombocytopenia (NAIT) is currently under debate. We evaluated the detection rate for NAIT in a nonscreened population of 661 200 births where NAIT was diagnosed on clinical indication. We did a cross‐sectional compariso...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2009-03, Vol.116 (4), p.594-598
Main Authors: Tiller, H, Killie, MK, Skogen, B, Øian, P, Husebekk, A
Format: Article
Language:English
Subjects:
Antenatal screening
Antigens, Human Platelet - blood
anti‐HPA1a antibodies
Biological and medical sciences
Blood diseases
Cross-Sectional Studies
Early Diagnosis
Female
Fetuses
Gynecology. Andrology. Obstetrics
Hematologic and hematopoietic diseases
Humans
Infant, Newborn
Medical sciences
Medical screening
NAIT detection rate
neonatal alloimmune thrombocytopenia
Norway - epidemiology
Platelet diseases and coagulopathies
Polymerase Chain Reaction
Pregnancy
Prenatal care
Prenatal Diagnosis - methods
Thrombocytopenia, Neonatal Alloimmune - diagnosis
Thrombocytopenia, Neonatal Alloimmune - epidemiology
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Summary:The implementation of an antenatal screening programme for neonatal alloimmune thrombocytopenia (NAIT) is currently under debate. We evaluated the detection rate for NAIT in a nonscreened population of 661 200 births where NAIT was diagnosed on clinical indication. We did a cross‐sectional comparison with a population of 100 448 human platelet antigen 1a (HPA1a)‐screened pregnancies from three of the five health regions in Norway. In a nonscreening situation, 7.5 cases of NAIT were detected per year compared with 53 cases when screening was applied. The detection rate of NAIT in Norway was therefore 14% of the expected rate.
ISSN:1470-0328
1471-0528
DOI:10.1111/j.1471-0528.2008.02068.x