Association of the M55L and Q192R paraoxonase gene polymorphisms with age-related macular degeneration

To investigate the reported association of the two single-nucleotide polymorphisms (SNPs) of the paraoxonase gene (PON1), Met-Leu 55 (M55L) and Gln-Arg 192 (Q192R), in individuals of Anglo-Celtic descent who have age-related macular degeneration (AMD). Case-control association study. Sixty-two indiv...

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Bibliographic Details
Published in:American journal of ophthalmology 2004-10, Vol.138 (4), p.665-666
Main Authors: Baird, Paul N., Chu, Diep, Guida, Elizabeth, Vu, Hien T.V., Guymer, Robyn
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alleles
Aryldialkylphosphatase - genetics
Biological and medical sciences
Case-Control Studies
Female
Gene Frequency
Genotype & phenotype
Humans
Macular degeneration
Macular Degeneration - enzymology
Macular Degeneration - ethnology
Macular Degeneration - genetics
Male
Medical sciences
Middle Aged
Ophthalmology
Polymerase Chain Reaction
Polymorphism, Single Nucleotide - genetics
Retinopathies
Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the eye and orbit
Victoria - epidemiology
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Summary:To investigate the reported association of the two single-nucleotide polymorphisms (SNPs) of the paraoxonase gene (PON1), Met-Leu 55 (M55L) and Gln-Arg 192 (Q192R), in individuals of Anglo-Celtic descent who have age-related macular degeneration (AMD). Case-control association study. Sixty-two individuals with late (end-stage) AMD and 115 control subjects (without AMD) were included in this study. The M55L and Q192R SNPs were amplified by polymerase chain reaction and genotyped, and statistical analysis was undertaken. No association of either SNP was detected in persons of Anglo-Celtic descent who had AMD, although there was a significant difference in SNP allele frequency between Anglo-Celtic and Japanese individuals. The M55L and Q192R SNPs of the PON1 gene do not appear to be associated with late AMD in individuals of Anglo-Celtic descent.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2004.04.053