Circulating concentrations of cardiac proteins in complicated and uncomplicated Plasmodium falciparum malaria

Summary In an unmatched case–control study of 63 non‐immune European patients with uncomplicated (n = 52) and complicated (n = 11) falciparum malaria, serum levels of N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), heart‐type fatty acid‐binding protein (H‐FABP), myoglobin, troponin T and creat...

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Bibliographic Details
Published in:Tropical medicine & international health 2004-10, Vol.9 (10), p.1099-1103
Main Authors: Ehrhardt, S., Wichmann, D., Hemmer, C. J., Burchard, G. D., Brattig, N. W.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomarkers - blood
Blood Proteins - analysis
cardiac impairment
Cardiomyopathies - blood
Cardiomyopathies - parasitology
Carrier Proteins - blood
Case-Control Studies
Comparative analysis
Creatine Kinase - blood
Creatine Kinase, MB Form
Fatty Acid-Binding Proteins
Heart
heart‐type fatty acid‐binding protein
Human protozoal diseases
Humans
Infectious diseases
Isoenzymes - blood
Malaria
Malaria, Falciparum - blood
Malaria, Falciparum - complications
Medical research
Medical sciences
myocard
Myoglobin - blood
Natriuretic Peptide, Brain
Nerve Tissue Proteins - blood
N‐terminal pro‐brain natriuretic peptide
Parasitic diseases
Peptide Fragments - blood
Plasmodium falciparum
Proteins
Protozoal diseases
troponin
Troponin T - blood
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Summary:Summary In an unmatched case–control study of 63 non‐immune European patients with uncomplicated (n = 52) and complicated (n = 11) falciparum malaria, serum levels of N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), heart‐type fatty acid‐binding protein (H‐FABP), myoglobin, troponin T and creatin kinase‐muscle brain were compared. Elevated levels of NT‐proBNP and H‐FABP indicated myocardial impairment in complicated but not in uncomplicated falciparum malaria. The clinical impact of these findings remains to be evaluated. The pathophysiology of cardiac impairment in complicated falciparum malaria warrants further investigation.
ISSN:1360-2276
1365-3156
DOI:10.1111/j.1365-3156.2004.01303.x