Changes in acetylcholinesterase (AchE) activity in lymphocytes and whole blood in acute lymphoblastic leukemia patients

Acute lymphoblastic leukemia (ALL) is a type of cancer that affects lymphocytes and it is the most common form of cancer in children. Acetylcholinesterase (AChE) is well known as having non-cholinergic functions and has been detected in the blood and plasma of humans including in lymphocytes. Thus,...

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Bibliographic Details
Published in:Clinica chimica acta 2009-04, Vol.402 (1), p.114-118
Main Authors: Battisti, Vanessa, Schetinger, Maria R.C., Maders, Liési D.K., Santos, Karen F., Bagatini, Margarete D., Correa, Maísa C., Spanevello, Rosélia M., do Carmo Araújo, Maria, Morsch, Vera M.
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Acetylcholinesterase - blood
Acetylcholinesterase - metabolism
Acute lymphoblastic leukemia (ALL)
Adolescent
Antineoplastic Agents - pharmacology
Child
Child, Preschool
Cytarabine - pharmacology
Female
Humans
Lymphocyte
Lymphocytes - drug effects
Lymphocytes - enzymology
Male
Methotrexate - pharmacology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology
Whole blood
Young Adult
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Summary:Acute lymphoblastic leukemia (ALL) is a type of cancer that affects lymphocytes and it is the most common form of cancer in children. Acetylcholinesterase (AChE) is well known as having non-cholinergic functions and has been detected in the blood and plasma of humans including in lymphocytes. Thus, we investigated whole blood and lymphocyte AChE activity in patients with ALL. This study was performed on 72 children with ALL divided into 4 groups: newly diagnosed, remission induction, remission maintenance and out-of-treatment and one control group of 50 healthy subjects. We determined AChE activity in whole blood and lymphocytes of these patients. Results demonstrated that whole blood AChE activity was enhanced in the newly diagnosed group and reduced in the remission induction and remission maintenance groups in relation to the control group. For lymphocyte AChE activity we found an increase in the newly diagnosed group and a decrease in the remission induction group in relation to the control. These results suggest that AChE activity was altered in ALL patients. This fact may be related with the essential role played by AChE in the development of hematological disease and its contribution to the regulation of immune function.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2008.12.030