Solubilisation of griseofulvin in aqueous micellar solutions of diblock copolymers of ethylene oxide and 1,2-butylene oxide with lengthy B-blocks

The influence of hydrophobic-block length on solubilisation capacity was examined for micelles of E m B n copolymers (E = oxyethylene, B = oxybutylene, subscripts denote number-average block lengths in repeat units) with B-block lengths in the range of 30–76 and with E-blocks of sufficient length to...

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Bibliographic Details
Published in:International journal of pharmaceutics 2009-03, Vol.369 (1), p.196-198
Main Authors: Ribeiro, Maria Elenir N.P., Cavalcante, Igor Marques, Ricardo, Nágila M.P.S., Mai, Shao-Min, Attwood, David, Yeates, Stephen G., Booth, Colin
Format: Article
Language:English
Subjects:
Biological and medical sciences
Block copolymer micelles
Drug solubilisation
Epoxy Compounds - chemistry
Ethylene Oxide - chemistry
General pharmacology
Griseofulvin - chemistry
Hydrophobic and Hydrophilic Interactions
Medical sciences
Micelles
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymers - chemistry
Solubility
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Summary:The influence of hydrophobic-block length on solubilisation capacity was examined for micelles of E m B n copolymers (E = oxyethylene, B = oxybutylene, subscripts denote number-average block lengths in repeat units) with B-block lengths in the range of 30–76 and with E-blocks of sufficient length to ensure the formation of spherical micelles. Griseofulvin was used as a model poorly-water-soluble drug known to be almost exclusively solubilised in the micellar core. Combination of solubilisation data with those of a previous study has shown that the amount of drug solubilised per gram of hydrophobe is essentially independent of B-block length when this exceeds about 15 B units, suggesting that core size is not a major influence on solubilisation.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2008.10.030