Idiopathic Infantile Pyoderma Gangrenosum with Stridor Responsive to Infliximab

:  A 4‐month‐old female infant presented with widespread pyoderma gangrenosum associated with stridor, presumed secondary to tracheal involvement. No underlying cause was revealed despite extensive investigation. Treatment with immunosuppressive agents only partially suppressed disease activity. Com...

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Bibliographic Details
Published in:Pediatric dermatology 2009-01, Vol.26 (1), p.65-69
Main Authors: Rajan, Neil, Das, Sharmila, Taylor, Aileen, Abinun, Mario, Spencer, David, Carmichael, Andrew
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - administration & dosage
Antibodies, Monoclonal - administration & dosage
Biological and medical sciences
Bronchi - pathology
Dermatology
Female
General aspects
Humans
Infant
Infliximab
Medical sciences
Pyoderma Gangrenosum - complications
Pyoderma Gangrenosum - drug therapy
Pyoderma Gangrenosum - pathology
Respiratory Mucosa - pathology
Respiratory Sounds - etiology
Skin - pathology
Skin involvement in other diseases. Miscellaneous. General aspects
Trachea - pathology
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Description
Summary::  A 4‐month‐old female infant presented with widespread pyoderma gangrenosum associated with stridor, presumed secondary to tracheal involvement. No underlying cause was revealed despite extensive investigation. Treatment with immunosuppressive agents only partially suppressed disease activity. Complete resolution followed treatment with infliximab. We review this rare condition in infants and discuss treatment with infliximab not previously described in this age group.
ISSN:0736-8046
1525-1470
DOI:10.1111/j.1525-1470.2008.00825.x