Human bone marrow adipocytes support complete myeloid and lymphoid differentiation from human CD34+ cells

Summary In humans, the role of bone marrow (BM) adipocytes in supporting haematopoiesis has been questioned. A co‐culture system of CD34+ cells seeded onto either BM undifferentiated mesenchymal stem cells or differentiated adipocytes showed that BM adipocytes did not support the maintenance of imma...

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Bibliographic Details
Published in:British journal of haematology 2004-11, Vol.127 (3), p.344-347
Main Authors: Corre, Jill, Planat‐Benard, Valérie, Corberand, Joël X., Pénicaud, Luc, Casteilla, Louis, Laharrague, Patrick
Format: Article
Language:English
Subjects:
adipocytes
Adipocytes - cytology
Adult
Aged
Aged, 80 and over
Antigens, CD34
Biological and medical sciences
bone marrow
Bone Marrow Cells - cytology
Cell Differentiation
Coculture Techniques
haematopoiesis
Hematologic and hematopoietic diseases
Humans
Lymphocytes - cytology
Medical sciences
microenvironment
Middle Aged
stromal cells
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Summary:Summary In humans, the role of bone marrow (BM) adipocytes in supporting haematopoiesis has been questioned. A co‐culture system of CD34+ cells seeded onto either BM undifferentiated mesenchymal stem cells or differentiated adipocytes showed that BM adipocytes did not support the maintenance of immature progenitors but enabled their complete differentiation along the myeloid and lymphoid pathways. These properties appear to be opposite to those of osteoblasts, although both cell types share a common mesenchymal progenitor. These results suggest that stromal cells play a variety of roles in the haematopoietic microenvironment, which could be significant in situations such as osteoporosis or ageing.
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2004.05198.x