Spatial Relationships between the Pulmonary Veins and Sites of Complex Fractionated Atrial Electrograms During Atrial Fibrillation

Background: Pulmonary vein (PV) isolation is used for the treatment of atrial fibrillation (AF). Complex fractionated atrial electrogram (CFAE) mapping has been introduced to guide AF ablation. However, the spatial relationship between PV and CFAE is not well defined. Methods and Results: The study...

Full description

Saved in:
Bibliographic Details
Published in:Pacing and clinical electrophysiology 2009-03, Vol.32 (s1), p.S190-S193
Main Authors: CHEN, JIAN, OFF, MORTEN KRISTIAN, SOLHEIM, EIVIND, HOFF, PER IVAR, SCHUSTER, PETER, OHM, OLE-JØRGEN
Format: Article
Language:English
Subjects:
atrial fibrillation
Atrial Fibrillation - physiopathology
Atrial Fibrillation - surgery
electrogram
Electrophysiologic Techniques, Cardiac - methods
endocardial mapping
Female
Heart Atria
Heart Conduction System - physiopathology
Heart Conduction System - surgery
Humans
Male
Middle Aged
pulmonary vein
Pulmonary Veins - physiopathology
Pulmonary Veins - surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c5222-44df46abd07e8629c60dad7e78628cad0d65d5023c604bf94638bf1601e186e53
cites cdi_FETCH-LOGICAL-c5222-44df46abd07e8629c60dad7e78628cad0d65d5023c604bf94638bf1601e186e53
container_end_page S193
container_issue s1
container_start_page S190
container_title Pacing and clinical electrophysiology
container_volume 32
creator CHEN, JIAN
OFF, MORTEN KRISTIAN
SOLHEIM, EIVIND
HOFF, PER IVAR
SCHUSTER, PETER
OHM, OLE-JØRGEN
description Background: Pulmonary vein (PV) isolation is used for the treatment of atrial fibrillation (AF). Complex fractionated atrial electrogram (CFAE) mapping has been introduced to guide AF ablation. However, the spatial relationship between PV and CFAE is not well defined. Methods and Results: The study included 21 patients (mean age 57 ± 11 years, 17 men, 14 paroxysmal, two persistent, and five long‐standing persistent AF) referred for PV isolation. Electrograms were sampled for 8 seconds at each site during stable AF (13 induced). High‐frequency was defined as
doi_str_mv 10.1111/j.1540-8159.2008.02282.x
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66983314</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66983314</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5222-44df46abd07e8629c60dad7e78628cad0d65d5023c604bf94638bf1601e186e53</originalsourceid><addsrcrecordid>eNqNkMtu1DAUhi0EokPhFZBX7BJsJ3acDdJomHSAqlQUytJy4pPWQ27YiTrd9snrkKFs8cbH-i_H-hDClMQ0nPf7mPKURJLyPGaEyJgwJll8eIZWT8JztCI0zSKZyPwEvfJ-TwgRJOUv0QnNGSckpyv0cDXo0eoGf4MmDH3nb-3gcQnjHUCHx1vAl1PT9p129_gabOex7gy-siN43Nd407dDAwdcOF3NcT2CwevRzZXbBqrR9TdOtx5_nJztbv5KhS2dbZaNr9GLWjce3hzvU_Sj2H7f7KLzr2efNuvzqOKMsShNTZ0KXRqSgRQsrwQx2mSQhYestCFGcMMJS4KQlnWeikSWNRWEApUCeHKK3i29g-t_T-BH1VpfQfhFB_3klRC5TBKaBqNcjJXrvXdQq8HZNgBQlKiZv9qrGbOaMauZv_rDXx1C9O1xx1S2YP4Fj8CD4cNiuLMN3P93sbpcb7bzGAqipcD6EQ5PBdr9UiJLMq5-Xpypz1-ud7uiYOoieQSI3KVR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66983314</pqid></control><display><type>article</type><title>Spatial Relationships between the Pulmonary Veins and Sites of Complex Fractionated Atrial Electrograms During Atrial Fibrillation</title><source>Wiley</source><source>SPORTDiscus with Full Text (EBSCO)</source><creator>CHEN, JIAN ; OFF, MORTEN KRISTIAN ; SOLHEIM, EIVIND ; HOFF, PER IVAR ; SCHUSTER, PETER ; OHM, OLE-JØRGEN</creator><creatorcontrib>CHEN, JIAN ; OFF, MORTEN KRISTIAN ; SOLHEIM, EIVIND ; HOFF, PER IVAR ; SCHUSTER, PETER ; OHM, OLE-JØRGEN</creatorcontrib><description>Background: Pulmonary vein (PV) isolation is used for the treatment of atrial fibrillation (AF). Complex fractionated atrial electrogram (CFAE) mapping has been introduced to guide AF ablation. However, the spatial relationship between PV and CFAE is not well defined. Methods and Results: The study included 21 patients (mean age 57 ± 11 years, 17 men, 14 paroxysmal, two persistent, and five long‐standing persistent AF) referred for PV isolation. Electrograms were sampled for 8 seconds at each site during stable AF (13 induced). High‐frequency was defined as &lt;80 ms of CFAE value. The distance between CFAE and the nearest PV ostium was measured. The PV ostia and antra were demarcated by fluoroscopy guidance and endocardial reconstruction. Among 82 PV mapped (left common four, superior 17, inferior 17; right superior 21, inferior 21, middle 2), 52.4% and 25.6% of high‐frequency CFAE were located on the anterior and posterior walls, respectively, inside the PV or at the ostium. No high‐frequency CFAE was observed in two out of 60 and one out of 20 PV anteriorly, versus seven out of 60 and 11 out of 20 PV (P &lt; 0.001) posteriorly, in paroxysmal and persistent AF, respectively. In the PV with high‐frequency CFAE, the mean shortest distances to the PV ostia in paroxysmal versus persistent AF were 2.7 ± 5.1 versus 7.4 ± 5.4 mm anteriorly (P &lt; 0.01), and 6.5 ± 6.4 versus 9.4 ± 8.4 mm posteriorly (ns). Conclusions: During PV isolation, extending the ablation lesions by up to 10 mm from the PV ostia might cover most high‐frequency CFAE around the PV antra. High‐frequency CFAE were more often located in the PV ostia in paroxysmal than in persistent AF.</description><identifier>ISSN: 0147-8389</identifier><identifier>EISSN: 1540-8159</identifier><identifier>DOI: 10.1111/j.1540-8159.2008.02282.x</identifier><identifier>PMID: 19250091</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>atrial fibrillation ; Atrial Fibrillation - physiopathology ; Atrial Fibrillation - surgery ; electrogram ; Electrophysiologic Techniques, Cardiac - methods ; endocardial mapping ; Female ; Heart Atria ; Heart Conduction System - physiopathology ; Heart Conduction System - surgery ; Humans ; Male ; Middle Aged ; pulmonary vein ; Pulmonary Veins - physiopathology ; Pulmonary Veins - surgery</subject><ispartof>Pacing and clinical electrophysiology, 2009-03, Vol.32 (s1), p.S190-S193</ispartof><rights>2009, The Authors. Journal compilation ©2009 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5222-44df46abd07e8629c60dad7e78628cad0d65d5023c604bf94638bf1601e186e53</citedby><cites>FETCH-LOGICAL-c5222-44df46abd07e8629c60dad7e78628cad0d65d5023c604bf94638bf1601e186e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19250091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHEN, JIAN</creatorcontrib><creatorcontrib>OFF, MORTEN KRISTIAN</creatorcontrib><creatorcontrib>SOLHEIM, EIVIND</creatorcontrib><creatorcontrib>HOFF, PER IVAR</creatorcontrib><creatorcontrib>SCHUSTER, PETER</creatorcontrib><creatorcontrib>OHM, OLE-JØRGEN</creatorcontrib><title>Spatial Relationships between the Pulmonary Veins and Sites of Complex Fractionated Atrial Electrograms During Atrial Fibrillation</title><title>Pacing and clinical electrophysiology</title><addtitle>Pacing Clin Electrophysiol</addtitle><description>Background: Pulmonary vein (PV) isolation is used for the treatment of atrial fibrillation (AF). Complex fractionated atrial electrogram (CFAE) mapping has been introduced to guide AF ablation. However, the spatial relationship between PV and CFAE is not well defined. Methods and Results: The study included 21 patients (mean age 57 ± 11 years, 17 men, 14 paroxysmal, two persistent, and five long‐standing persistent AF) referred for PV isolation. Electrograms were sampled for 8 seconds at each site during stable AF (13 induced). High‐frequency was defined as &lt;80 ms of CFAE value. The distance between CFAE and the nearest PV ostium was measured. The PV ostia and antra were demarcated by fluoroscopy guidance and endocardial reconstruction. Among 82 PV mapped (left common four, superior 17, inferior 17; right superior 21, inferior 21, middle 2), 52.4% and 25.6% of high‐frequency CFAE were located on the anterior and posterior walls, respectively, inside the PV or at the ostium. No high‐frequency CFAE was observed in two out of 60 and one out of 20 PV anteriorly, versus seven out of 60 and 11 out of 20 PV (P &lt; 0.001) posteriorly, in paroxysmal and persistent AF, respectively. In the PV with high‐frequency CFAE, the mean shortest distances to the PV ostia in paroxysmal versus persistent AF were 2.7 ± 5.1 versus 7.4 ± 5.4 mm anteriorly (P &lt; 0.01), and 6.5 ± 6.4 versus 9.4 ± 8.4 mm posteriorly (ns). Conclusions: During PV isolation, extending the ablation lesions by up to 10 mm from the PV ostia might cover most high‐frequency CFAE around the PV antra. High‐frequency CFAE were more often located in the PV ostia in paroxysmal than in persistent AF.</description><subject>atrial fibrillation</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Fibrillation - surgery</subject><subject>electrogram</subject><subject>Electrophysiologic Techniques, Cardiac - methods</subject><subject>endocardial mapping</subject><subject>Female</subject><subject>Heart Atria</subject><subject>Heart Conduction System - physiopathology</subject><subject>Heart Conduction System - surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>pulmonary vein</subject><subject>Pulmonary Veins - physiopathology</subject><subject>Pulmonary Veins - surgery</subject><issn>0147-8389</issn><issn>1540-8159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkMtu1DAUhi0EokPhFZBX7BJsJ3acDdJomHSAqlQUytJy4pPWQ27YiTrd9snrkKFs8cbH-i_H-hDClMQ0nPf7mPKURJLyPGaEyJgwJll8eIZWT8JztCI0zSKZyPwEvfJ-TwgRJOUv0QnNGSckpyv0cDXo0eoGf4MmDH3nb-3gcQnjHUCHx1vAl1PT9p129_gabOex7gy-siN43Nd407dDAwdcOF3NcT2CwevRzZXbBqrR9TdOtx5_nJztbv5KhS2dbZaNr9GLWjce3hzvU_Sj2H7f7KLzr2efNuvzqOKMsShNTZ0KXRqSgRQsrwQx2mSQhYestCFGcMMJS4KQlnWeikSWNRWEApUCeHKK3i29g-t_T-BH1VpfQfhFB_3klRC5TBKaBqNcjJXrvXdQq8HZNgBQlKiZv9qrGbOaMauZv_rDXx1C9O1xx1S2YP4Fj8CD4cNiuLMN3P93sbpcb7bzGAqipcD6EQ5PBdr9UiJLMq5-Xpypz1-ud7uiYOoieQSI3KVR</recordid><startdate>200903</startdate><enddate>200903</enddate><creator>CHEN, JIAN</creator><creator>OFF, MORTEN KRISTIAN</creator><creator>SOLHEIM, EIVIND</creator><creator>HOFF, PER IVAR</creator><creator>SCHUSTER, PETER</creator><creator>OHM, OLE-JØRGEN</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200903</creationdate><title>Spatial Relationships between the Pulmonary Veins and Sites of Complex Fractionated Atrial Electrograms During Atrial Fibrillation</title><author>CHEN, JIAN ; OFF, MORTEN KRISTIAN ; SOLHEIM, EIVIND ; HOFF, PER IVAR ; SCHUSTER, PETER ; OHM, OLE-JØRGEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5222-44df46abd07e8629c60dad7e78628cad0d65d5023c604bf94638bf1601e186e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>atrial fibrillation</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrial Fibrillation - surgery</topic><topic>electrogram</topic><topic>Electrophysiologic Techniques, Cardiac - methods</topic><topic>endocardial mapping</topic><topic>Female</topic><topic>Heart Atria</topic><topic>Heart Conduction System - physiopathology</topic><topic>Heart Conduction System - surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>pulmonary vein</topic><topic>Pulmonary Veins - physiopathology</topic><topic>Pulmonary Veins - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHEN, JIAN</creatorcontrib><creatorcontrib>OFF, MORTEN KRISTIAN</creatorcontrib><creatorcontrib>SOLHEIM, EIVIND</creatorcontrib><creatorcontrib>HOFF, PER IVAR</creatorcontrib><creatorcontrib>SCHUSTER, PETER</creatorcontrib><creatorcontrib>OHM, OLE-JØRGEN</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pacing and clinical electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHEN, JIAN</au><au>OFF, MORTEN KRISTIAN</au><au>SOLHEIM, EIVIND</au><au>HOFF, PER IVAR</au><au>SCHUSTER, PETER</au><au>OHM, OLE-JØRGEN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spatial Relationships between the Pulmonary Veins and Sites of Complex Fractionated Atrial Electrograms During Atrial Fibrillation</atitle><jtitle>Pacing and clinical electrophysiology</jtitle><addtitle>Pacing Clin Electrophysiol</addtitle><date>2009-03</date><risdate>2009</risdate><volume>32</volume><issue>s1</issue><spage>S190</spage><epage>S193</epage><pages>S190-S193</pages><issn>0147-8389</issn><eissn>1540-8159</eissn><abstract>Background: Pulmonary vein (PV) isolation is used for the treatment of atrial fibrillation (AF). Complex fractionated atrial electrogram (CFAE) mapping has been introduced to guide AF ablation. However, the spatial relationship between PV and CFAE is not well defined. Methods and Results: The study included 21 patients (mean age 57 ± 11 years, 17 men, 14 paroxysmal, two persistent, and five long‐standing persistent AF) referred for PV isolation. Electrograms were sampled for 8 seconds at each site during stable AF (13 induced). High‐frequency was defined as &lt;80 ms of CFAE value. The distance between CFAE and the nearest PV ostium was measured. The PV ostia and antra were demarcated by fluoroscopy guidance and endocardial reconstruction. Among 82 PV mapped (left common four, superior 17, inferior 17; right superior 21, inferior 21, middle 2), 52.4% and 25.6% of high‐frequency CFAE were located on the anterior and posterior walls, respectively, inside the PV or at the ostium. No high‐frequency CFAE was observed in two out of 60 and one out of 20 PV anteriorly, versus seven out of 60 and 11 out of 20 PV (P &lt; 0.001) posteriorly, in paroxysmal and persistent AF, respectively. In the PV with high‐frequency CFAE, the mean shortest distances to the PV ostia in paroxysmal versus persistent AF were 2.7 ± 5.1 versus 7.4 ± 5.4 mm anteriorly (P &lt; 0.01), and 6.5 ± 6.4 versus 9.4 ± 8.4 mm posteriorly (ns). Conclusions: During PV isolation, extending the ablation lesions by up to 10 mm from the PV ostia might cover most high‐frequency CFAE around the PV antra. High‐frequency CFAE were more often located in the PV ostia in paroxysmal than in persistent AF.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>19250091</pmid><doi>10.1111/j.1540-8159.2008.02282.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0147-8389
ispartof Pacing and clinical electrophysiology, 2009-03, Vol.32 (s1), p.S190-S193
issn 0147-8389
1540-8159
language eng
recordid cdi_proquest_miscellaneous_66983314
source Wiley; SPORTDiscus with Full Text (EBSCO)
subjects atrial fibrillation
Atrial Fibrillation - physiopathology
Atrial Fibrillation - surgery
electrogram
Electrophysiologic Techniques, Cardiac - methods
endocardial mapping
Female
Heart Atria
Heart Conduction System - physiopathology
Heart Conduction System - surgery
Humans
Male
Middle Aged
pulmonary vein
Pulmonary Veins - physiopathology
Pulmonary Veins - surgery
title Spatial Relationships between the Pulmonary Veins and Sites of Complex Fractionated Atrial Electrograms During Atrial Fibrillation
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T21%3A22%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Spatial%20Relationships%20between%20the%20Pulmonary%20Veins%20and%20Sites%20of%20Complex%20Fractionated%20Atrial%20Electrograms%20During%20Atrial%20Fibrillation&rft.jtitle=Pacing%20and%20clinical%20electrophysiology&rft.au=CHEN,%20JIAN&rft.date=2009-03&rft.volume=32&rft.issue=s1&rft.spage=S190&rft.epage=S193&rft.pages=S190-S193&rft.issn=0147-8389&rft.eissn=1540-8159&rft_id=info:doi/10.1111/j.1540-8159.2008.02282.x&rft_dat=%3Cproquest_cross%3E66983314%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5222-44df46abd07e8629c60dad7e78628cad0d65d5023c604bf94638bf1601e186e53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=66983314&rft_id=info:pmid/19250091&rfr_iscdi=true