Pituicytoma

• Published in: Annals of diagnostic pathology 2004-10, Vol.8 (5), p.290-294
• Main Authors: Kowalski, Robert J., Prayson, Richard A., Mayberg, Marc R.
• Format: Article
• Language: English
• Subjects: Biomarkers, Tumor - metabolism; Combined Modality Therapy; Glial Fibrillary Acidic Protein - metabolism; Glioma - metabolism; Glioma - pathology; Glioma - therapy; Humans; Immunoenzyme Techniques; Ki-67 Antigen - metabolism; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; neurohypophysis; Pituicytoma; pituitary gland; Pituitary Gland, Posterior - metabolism; Pituitary Gland, Posterior - pathology; Pituitary Gland, Posterior - surgery; Pituitary Neoplasms - metabolism; Pituitary Neoplasms - pathology; Pituitary Neoplasms - therapy; Radiotherapy, Adjuvant; S100 Proteins - metabolism; tumor
• ISSN: 1092-9134; 1532-8198
• DOI: 10.1016/j.anndiagpath.2004.07.006

Pituicytoma is a rare, low-grade neoplasm that originates in the neurohypophysis of the pituitary gland. We report the clinicopathologic features of a pituicytoma arising in a 52-year-old man who presented with a mass and panhypopituitarism, clinically suggestive of a pituitary adenoma. The tumor was marked by a proliferation of elongated cells arranged in bundles and interlacing fascicles. The tumor demonstrated positive staining with S-100 protein and glial fibrillary acid protein antibodies. The tumor did not stain with antibodies to cytokeratin, synaptophysin, chromogranin, anterior pituitary hormones, or p53. An MIB-1 labeling index of 1.1% was observed. The tumor was subtotally resected and recurred 11 months after the initial surgery. The literature on this rare tumor will be reviewed and differential diagnosis discussed.