The role of Shiga-toxin-producing Escherichia coli in hemorrhagic colitis and hemolytic uremic syndrome

The Shiga-toxin-producing E. coli represent a major class of pathogens that have been defined over the last twenty years. They cause distinctive clinical manifestations such as afebrile bloody diarrhea with severe abdominal pain (hemorrhagic colitis) and microangiopathic hemolytic anemia with renal...

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Bibliographic Details
Published in:Seminars in pediatric infectious diseases 2004-10, Vol.15 (4), p.260-265
Main Author: Cleary, Thomas G.
Format: Article
Language:English
Subjects:
Child, Preschool
Colitis - microbiology
Colitis - physiopathology
Escherichia coli Infections - diagnosis
Escherichia coli Infections - microbiology
Escherichia coli Infections - physiopathology
Escherichia coli O157 - metabolism
Escherichia coli O157 - pathogenicity
Gastrointestinal Hemorrhage - microbiology
Hemolytic-Uremic Syndrome - microbiology
Humans
Infant
Shiga Toxins - biosynthesis
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Summary:The Shiga-toxin-producing E. coli represent a major class of pathogens that have been defined over the last twenty years. They cause distinctive clinical manifestations such as afebrile bloody diarrhea with severe abdominal pain (hemorrhagic colitis) and microangiopathic hemolytic anemia with renal failure (hemolytic uremic syndrome). The most common Shiga-toxin-producing E. coli is serotype O157:H7, although at least one hundred different serotypes share the virulence traits and clinical manifestations with this organism. Understanding the pathophysicology, improving diagnostic tools, and developing a treatment strategy are important areas of ongoing investigations.
ISSN:1045-1870
1557-9387
DOI:10.1053/j.spid.2004.07.007