Scabrosin esters and derivatives: chemical derivatization studies and biological evaluation

[Display omitted] Several derivatives of the natural scabrosin esters were synthesized in order to elucidate the structural features present, which are responsible for the biological activities. The studies demonstrate that full anti-proliferative activities of the scabrosin esters, both the carbosk...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2004-11, Vol.12 (22), p.5991-5995
Main Authors: Chai, Christina L.L., Elix, John A., Huleatt, Paul B., Waring, Paul
Format: Article
Language:English
Subjects:
Animals
Anti-proliferative agents
Anti-tumour compounds
Antineoplastic agents
Biological and medical sciences
Biological Factors - chemistry
Biological Factors - isolation & purification
Biological Factors - pharmacology
Biological Products - chemical synthesis
Biological Products - pharmacology
Cell Line, Tumor
Drug Evaluation, Preclinical - methods
Esters
General aspects
Medical sciences
Mice
Natural products
Pharmacology. Drug treatments
Polycyclic heterocyclic compounds
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] Several derivatives of the natural scabrosin esters were synthesized in order to elucidate the structural features present, which are responsible for the biological activities. The studies demonstrate that full anti-proliferative activities of the scabrosin esters, both the carboskeleton core as well as the ability to form the dithiol and/or the disulfide linkage of the epidithiopiperazine-2,5-dione are required. The presence of the epoxide rings on the scabrosin esters do not contribute to the observed biological activities.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2004.08.015