Structural characterization and quantitation of compound loading of disubstituted benzoates bound to Wang resin through high-resolution magic angle spinning NMR spectroscopy

The combination of 1D and 2D high‐resolution magic angle spinning NMR experiments led to the assignment of the proton and carbon resonances for several disubstituted benzoates bound to a polystyrene resin through a Wang linker. It is shown that the signal corresponding to the methylene protons of th...

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Bibliographic Details
Published in:Magnetic resonance in chemistry 2004-11, Vol.42 (11), p.950-954
Main Authors: Blas, Jesús, Rivera-Sagredo, Alfonso, Ferritto, Rafael, Espinosa, Juan Felix
Format: Article
Language:English
Subjects:
13C NMR
1H NMR
high-resolution magic angle spinning
NMR
solid-phase synthesis
Wang linker
Wang resin
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Summary:The combination of 1D and 2D high‐resolution magic angle spinning NMR experiments led to the assignment of the proton and carbon resonances for several disubstituted benzoates bound to a polystyrene resin through a Wang linker. It is shown that the signal corresponding to the methylene protons of the linker can be utilized to monitor the solid‐phase reactions and determine the loading of the compounds on the resin. Copyright © 2004 John Wiley & Sons, Ltd.
ISSN:0749-1581
1097-458X
DOI:10.1002/mrc.1478