Risk factors for hip fracture in Japanese elderly women with osteoporosis: Applicability of biochemical markers in bone turnover

• Published in: Geriatrics & gerontology international 2009-03, Vol.9 (1), p.69-74
• Main Authors: Shiga, Toshiki, Tsuji, Yoshiro, Fujioka, Mikihiro, Kubo, Toshikazu
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Alkaline Phosphatase - blood; Amino Acids - urine; biochemical marker; Bone and Bones - metabolism; Bone density; bone turnover; Female; Fractures; hip fracture; Hip Fractures - epidemiology; Hip Fractures - etiology; Hip joint; Humans; Japan - epidemiology; Middle Aged; Older people; Osteoporosis; Osteoporosis - complications; Osteoporosis - metabolism; risk factor; Risk Factors; Spine; Women
• ISSN: 1444-1586; 1447-0594
• DOI: 10.1111/j.1447-0594.2008.00510.x

Aim:  The purpose of this study was to investigate risk factors for hip fracture in 169 Japanese elderly women. Methods:  Patients were divided into three groups: 53 patients had osteoporosis with hip fractures (FX‐G), 59 patients had osteoporosis without hip fractures (NFX‐G) and 57 patients had low back pain with neither osteoporosis nor hip fracture (NOP‐G). Bone mineral density (BMD) of lumbar spine, bone‐specific alkaline phosphatase (BAP) and deoxypyridinoline (DPD) were compared among the three groups. Results:  The mean BMD of FX‐G and NFX‐G was lower than that of NOP‐G, but there was no significant difference between FX‐G and NFX‐G. Although the mean BAP of FX‐G was similar to that of NOP‐G, both were lower than NFX‐G (P