Risk factors for hip fracture in Japanese elderly women with osteoporosis: Applicability of biochemical markers in bone turnover

Aim:  The purpose of this study was to investigate risk factors for hip fracture in 169 Japanese elderly women. Methods:  Patients were divided into three groups: 53 patients had osteoporosis with hip fractures (FX‐G), 59 patients had osteoporosis without hip fractures (NFX‐G) and 57 patients had lo...

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Published in:Geriatrics & gerontology international 2009-03, Vol.9 (1), p.69-74
Main Authors: Shiga, Toshiki, Tsuji, Yoshiro, Fujioka, Mikihiro, Kubo, Toshikazu
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alkaline Phosphatase - blood
Amino Acids - urine
biochemical marker
Bone and Bones - metabolism
Bone density
bone turnover
Female
Fractures
hip fracture
Hip Fractures - epidemiology
Hip Fractures - etiology
Hip joint
Humans
Japan - epidemiology
Middle Aged
Older people
Osteoporosis
Osteoporosis - complications
Osteoporosis - metabolism
risk factor
Risk Factors
Spine
Women
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Tsuji, Yoshiro
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description Aim:  The purpose of this study was to investigate risk factors for hip fracture in 169 Japanese elderly women. Methods:  Patients were divided into three groups: 53 patients had osteoporosis with hip fractures (FX‐G), 59 patients had osteoporosis without hip fractures (NFX‐G) and 57 patients had low back pain with neither osteoporosis nor hip fracture (NOP‐G). Bone mineral density (BMD) of lumbar spine, bone‐specific alkaline phosphatase (BAP) and deoxypyridinoline (DPD) were compared among the three groups. Results:  The mean BMD of FX‐G and NFX‐G was lower than that of NOP‐G, but there was no significant difference between FX‐G and NFX‐G. Although the mean BAP of FX‐G was similar to that of NOP‐G, both were lower than NFX‐G (P 
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Methods:  Patients were divided into three groups: 53 patients had osteoporosis with hip fractures (FX‐G), 59 patients had osteoporosis without hip fractures (NFX‐G) and 57 patients had low back pain with neither osteoporosis nor hip fracture (NOP‐G). Bone mineral density (BMD) of lumbar spine, bone‐specific alkaline phosphatase (BAP) and deoxypyridinoline (DPD) were compared among the three groups. Results:  The mean BMD of FX‐G and NFX‐G was lower than that of NOP‐G, but there was no significant difference between FX‐G and NFX‐G. Although the mean BAP of FX‐G was similar to that of NOP‐G, both were lower than NFX‐G (P &lt; 0.05). However, the mean DPD of FX‐G was higher than the other groups (P &lt; 0.05, vs NFX‐G, P &lt; 0.001, vs NOP‐G). The percentage of patients who showed BAP levels less than 35 IU/L and DPD levels of 7.5 nmoL/mmol‐Cr or more, was highest in FX‐G (72.7%). This percentage was lower for NFX‐G (30.9%) and NOP‐G (16.4%). The odds ratio of hip fracture occurring was 5.77 (95% confidence interval, 2.25−14.66). Conclusion:  Bone turnover consisting of increase in bone resorption and decrease in bone formation apart from BMD of lumbar spine resulted in a higher incidence of hip fracture for Japanese elderly women with osteoporosis.</description><identifier>ISSN: 1444-1586</identifier><identifier>EISSN: 1447-0594</identifier><identifier>DOI: 10.1111/j.1447-0594.2008.00510.x</identifier><identifier>PMID: 19260982</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Aged ; Aged, 80 and over ; Alkaline Phosphatase - blood ; Amino Acids - urine ; biochemical marker ; Bone and Bones - metabolism ; Bone density ; bone turnover ; Female ; Fractures ; hip fracture ; Hip Fractures - epidemiology ; Hip Fractures - etiology ; Hip joint ; Humans ; Japan - epidemiology ; Middle Aged ; Older people ; Osteoporosis ; Osteoporosis - complications ; Osteoporosis - metabolism ; risk factor ; Risk Factors ; Spine ; Women</subject><ispartof>Geriatrics &amp; gerontology international, 2009-03, Vol.9 (1), p.69-74</ispartof><rights>2009 Japan Geriatrics Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4840-dd234101e8aa6037d986d65d82af897f77c4f1f6049a48823ccd0ec51c699b943</citedby><cites>FETCH-LOGICAL-c4840-dd234101e8aa6037d986d65d82af897f77c4f1f6049a48823ccd0ec51c699b943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19260982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shiga, Toshiki</creatorcontrib><creatorcontrib>Tsuji, Yoshiro</creatorcontrib><creatorcontrib>Fujioka, Mikihiro</creatorcontrib><creatorcontrib>Kubo, Toshikazu</creatorcontrib><title>Risk factors for hip fracture in Japanese elderly women with osteoporosis: Applicability of biochemical markers in bone turnover</title><title>Geriatrics &amp; gerontology international</title><addtitle>Geriatr Gerontol Int</addtitle><description>Aim:  The purpose of this study was to investigate risk factors for hip fracture in 169 Japanese elderly women. Methods:  Patients were divided into three groups: 53 patients had osteoporosis with hip fractures (FX‐G), 59 patients had osteoporosis without hip fractures (NFX‐G) and 57 patients had low back pain with neither osteoporosis nor hip fracture (NOP‐G). Bone mineral density (BMD) of lumbar spine, bone‐specific alkaline phosphatase (BAP) and deoxypyridinoline (DPD) were compared among the three groups. Results:  The mean BMD of FX‐G and NFX‐G was lower than that of NOP‐G, but there was no significant difference between FX‐G and NFX‐G. Although the mean BAP of FX‐G was similar to that of NOP‐G, both were lower than NFX‐G (P &lt; 0.05). However, the mean DPD of FX‐G was higher than the other groups (P &lt; 0.05, vs NFX‐G, P &lt; 0.001, vs NOP‐G). The percentage of patients who showed BAP levels less than 35 IU/L and DPD levels of 7.5 nmoL/mmol‐Cr or more, was highest in FX‐G (72.7%). This percentage was lower for NFX‐G (30.9%) and NOP‐G (16.4%). The odds ratio of hip fracture occurring was 5.77 (95% confidence interval, 2.25−14.66). Conclusion:  Bone turnover consisting of increase in bone resorption and decrease in bone formation apart from BMD of lumbar spine resulted in a higher incidence of hip fracture for Japanese elderly women with osteoporosis.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alkaline Phosphatase - blood</subject><subject>Amino Acids - urine</subject><subject>biochemical marker</subject><subject>Bone and Bones - metabolism</subject><subject>Bone density</subject><subject>bone turnover</subject><subject>Female</subject><subject>Fractures</subject><subject>hip fracture</subject><subject>Hip Fractures - epidemiology</subject><subject>Hip Fractures - etiology</subject><subject>Hip joint</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Osteoporosis</subject><subject>Osteoporosis - complications</subject><subject>Osteoporosis - metabolism</subject><subject>risk factor</subject><subject>Risk Factors</subject><subject>Spine</subject><subject>Women</subject><issn>1444-1586</issn><issn>1447-0594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNUcFu1DAQjRCIlsIvIIsDtyx24jg24lJVNC2qoKpAlXqxHGes9TZZp3aW3b3x6Z3trorECV88mnnveZ5flhFGZwzPp8WMcV7ntFJ8VlAqZ5RWONu8yI6fBy-fap6zSoqj7E1KC0pZrRh7nR0xVQiqZHGc_bnx6Z44Y6cQE3EhkrkfiYvYWEUgfkm-mdEsIQGBvoPYb8k6DLAkaz_NSUgThDHEkHz6TE7HsffWtL7305YER1of7BwG7PVkMPEe8AlUbMMSCMovw2-Ib7NXzvQJ3h3uk-zX-defZxf51Y_m8uz0Krdccpp3XVFyRhlIYwQt605J0Ymqk4VxUtWuri13zAnKleFSFqW1HQVbMSuUahUvT7KPe90xhocVpEkPPlnoezQXVkkLxKmqqBH44R_gIuCuuJsuCimFYFQhSO5BFr2nCE6P0aPFrWZU7yLSC71LQu-S0LuI9FNEeoPU9wf9VTtA95d4yAQBX_aAte9h-9_CumkusUB6vqd7DGfzTMfv16Iu60rffm_0zbW8vm3O7_Rd-Qg3H7Am</recordid><startdate>200903</startdate><enddate>200903</enddate><creator>Shiga, Toshiki</creator><creator>Tsuji, Yoshiro</creator><creator>Fujioka, Mikihiro</creator><creator>Kubo, Toshikazu</creator><general>Blackwell Publishing Asia</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200903</creationdate><title>Risk factors for hip fracture in Japanese elderly women with osteoporosis: Applicability of biochemical markers in bone turnover</title><author>Shiga, Toshiki ; Tsuji, Yoshiro ; Fujioka, Mikihiro ; Kubo, Toshikazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4840-dd234101e8aa6037d986d65d82af897f77c4f1f6049a48823ccd0ec51c699b943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alkaline Phosphatase - blood</topic><topic>Amino Acids - urine</topic><topic>biochemical marker</topic><topic>Bone and Bones - metabolism</topic><topic>Bone density</topic><topic>bone turnover</topic><topic>Female</topic><topic>Fractures</topic><topic>hip fracture</topic><topic>Hip Fractures - epidemiology</topic><topic>Hip Fractures - etiology</topic><topic>Hip joint</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Osteoporosis</topic><topic>Osteoporosis - complications</topic><topic>Osteoporosis - metabolism</topic><topic>risk factor</topic><topic>Risk Factors</topic><topic>Spine</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shiga, Toshiki</creatorcontrib><creatorcontrib>Tsuji, Yoshiro</creatorcontrib><creatorcontrib>Fujioka, Mikihiro</creatorcontrib><creatorcontrib>Kubo, Toshikazu</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Geriatrics &amp; gerontology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shiga, Toshiki</au><au>Tsuji, Yoshiro</au><au>Fujioka, Mikihiro</au><au>Kubo, Toshikazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for hip fracture in Japanese elderly women with osteoporosis: Applicability of biochemical markers in bone turnover</atitle><jtitle>Geriatrics &amp; gerontology international</jtitle><addtitle>Geriatr Gerontol Int</addtitle><date>2009-03</date><risdate>2009</risdate><volume>9</volume><issue>1</issue><spage>69</spage><epage>74</epage><pages>69-74</pages><issn>1444-1586</issn><eissn>1447-0594</eissn><abstract>Aim:  The purpose of this study was to investigate risk factors for hip fracture in 169 Japanese elderly women. Methods:  Patients were divided into three groups: 53 patients had osteoporosis with hip fractures (FX‐G), 59 patients had osteoporosis without hip fractures (NFX‐G) and 57 patients had low back pain with neither osteoporosis nor hip fracture (NOP‐G). Bone mineral density (BMD) of lumbar spine, bone‐specific alkaline phosphatase (BAP) and deoxypyridinoline (DPD) were compared among the three groups. Results:  The mean BMD of FX‐G and NFX‐G was lower than that of NOP‐G, but there was no significant difference between FX‐G and NFX‐G. Although the mean BAP of FX‐G was similar to that of NOP‐G, both were lower than NFX‐G (P &lt; 0.05). However, the mean DPD of FX‐G was higher than the other groups (P &lt; 0.05, vs NFX‐G, P &lt; 0.001, vs NOP‐G). The percentage of patients who showed BAP levels less than 35 IU/L and DPD levels of 7.5 nmoL/mmol‐Cr or more, was highest in FX‐G (72.7%). This percentage was lower for NFX‐G (30.9%) and NOP‐G (16.4%). The odds ratio of hip fracture occurring was 5.77 (95% confidence interval, 2.25−14.66). Conclusion:  Bone turnover consisting of increase in bone resorption and decrease in bone formation apart from BMD of lumbar spine resulted in a higher incidence of hip fracture for Japanese elderly women with osteoporosis.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>19260982</pmid><doi>10.1111/j.1447-0594.2008.00510.x</doi><tpages>6</tpages></addata></record>
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source Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list)
subjects Aged
Aged, 80 and over
Alkaline Phosphatase - blood
Amino Acids - urine
biochemical marker
Bone and Bones - metabolism
Bone density
bone turnover
Female
Fractures
hip fracture
Hip Fractures - epidemiology
Hip Fractures - etiology
Hip joint
Humans
Japan - epidemiology
Middle Aged
Older people
Osteoporosis
Osteoporosis - complications
Osteoporosis - metabolism
risk factor
Risk Factors
Spine
Women
title Risk factors for hip fracture in Japanese elderly women with osteoporosis: Applicability of biochemical markers in bone turnover
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