Design, synthesis, structure–activity relationship and antibacterial activity series of novel imidazo fused quinolone carboxamides

A series of novel 7,8 and 1,8 imidazo fused quinolone carboxamides are synthesized and evaluated against antibacterial activity. 1,8 Imidazo fused quinolones exhibit moderate antibacterial activity. Molecular modeling studies were carried out to optimize the pharmacophore. [Display omitted]

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Bibliographic Details
Published in:European journal of medicinal chemistry 2009-04, Vol.44 (4), p.1570-1578
Main Authors: Venkat Reddy, G., Ravi Kanth, S., Maitraie, D., Narsaiah, B., Shanthan Rao, P., Hara Kishore, K., Murthy, U.S.N., Ravi, B., Ashok Kumar, B., Parthasarathy, T.
Format: Article
Language:English
Subjects:
Amides - chemical synthesis
Amides - chemistry
Amides - pharmacology
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria - drug effects
Biological and medical sciences
Diamine
Drug Design
Imidazo fused
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
QSAR
Quinolines
Quinolones - chemistry
Structure-Activity Relationship
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Description
Summary:A series of novel 7,8 and 1,8 imidazo fused quinolone carboxamides are synthesized and evaluated against antibacterial activity. 1,8 Imidazo fused quinolones exhibit moderate antibacterial activity. Molecular modeling studies were carried out to optimize the pharmacophore. [Display omitted]
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2008.07.024