Hypoxic–ischemic brain injury in the term infant-current concepts

An enhanced understanding of the cellular characteristics contributing to ongoing brain injury following intrapartum hypoxia-ischemia has resulted in the implementation of targeted neuroprotective strategies in the newborn period. This review briefly covers the pathogenesis of hypoxic-ischemic injur...

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Bibliographic Details
Published in:Early human development 2004-11, Vol.80 (2), p.125-141
Main Authors: Shalak, Lina, Perlman, Jeffrey M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain - pathology
Cerebral Palsy - etiology
Embryology: invertebrates and vertebrates. Teratology
Fundamental and applied biological sciences. Psychology
Humans
Hypothermia, Induced
Hypoxia-Ischemia, Brain - complications
Hypoxia-Ischemia, Brain - pathology
Hypoxia-Ischemia, Brain - therapy
Hypoxic–ischemic brain injury
Infant, Newborn
Infant-current concepts cerebral palsy
Magnetic Resonance Imaging
Medical sciences
Neurology
Neuroprotective Agents - therapeutic use
Reperfusion Injury - etiology
Reperfusion Injury - pathology
Reperfusion Injury - therapy
Vascular diseases and vascular malformations of the nervous system
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Summary:An enhanced understanding of the cellular characteristics contributing to ongoing brain injury following intrapartum hypoxia-ischemia has resulted in the implementation of targeted neuroprotective strategies in the newborn period. This review briefly covers the pathogenesis of hypoxic-ischemic injury with an emphasis on reperfusion injury; the role of magnetic resonance imaging in the detection of such injury, and focuses on potential strategies both supportive and neuroprotective to prevent ongoing injury with a specific emphasis on modest hypothermia.
ISSN:0378-3782
1872-6232
DOI:10.1016/j.earlhumdev.2004.06.003