Association of Uric Acid With Inflammation, Progressive Renal Allograft Dysfunction and Post-Transplant Cardiovascular Risk

Hyperuricemia is common after kidney transplantation. Although its risk factors are well established, its relation to inflammation, progressive renal dysfunction, and cardiovascular events is unknown. In this study, 405 stable renal transplant recipients with ≥3 uric acid (UA) and C-reactive protein...

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Bibliographic Details
Published in:The American journal of cardiology 2009-03, Vol.103 (6), p.867-871
Main Authors: Bandukwala, Farah, MD, Huang, Michael, MSc, Zaltzman, Jeffrey S., MD, Nash, Michelle M., MSc, Prasad, G.V. Ramesh, MBBS
Format: Article
Language:English
Subjects:
Adult
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
C-Reactive Protein - analysis
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - complications
Cardiovascular Diseases - physiopathology
Confidence intervals
Correlation analysis
Female
Glomerular Filtration Rate
Humans
Hyperuricemia - complications
Inflammation
Kidney - physiopathology
Kidney diseases
Kidney Diseases - complications
Kidney Transplantation
Male
Medical sciences
Middle Aged
Risk Factors
Transplantation, Homologous
Transplants & implants
Uric Acid - blood
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Summary:Hyperuricemia is common after kidney transplantation. Although its risk factors are well established, its relation to inflammation, progressive renal dysfunction, and cardiovascular events is unknown. In this study, 405 stable renal transplant recipients with ≥3 uric acid (UA) and C-reactive protein measurements from January 2005 to April 2008 were identified to determine the relations between UA and C-reactive protein and between UA and the rate of decrease in the estimated glomerular filtration rate (eGFR; using the Modification of Diet in Renal Disease equation) and cardiovascular events. Hyperuricemia was defined as UA >7.1 mg/dl (420 μmol/L) in men and >6.1 mg/dl (360 μmol/L) in women. The prevalence of hyperuricemia was 44% (180 of 405). Hyperuricemia was negatively associated with eGFR (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2008.11.042