Effects of Testosterone on Ventricular Repolarization in Hypogonadic Men

QT-interval duration is shorter in men than in women. Estrogens do not significantly influence the duration of repolarization. The effect of testosterone has not been studied directly in humans. The aim of this study was to assess the effects of testosterone on corrected QT duration in hypogonadic m...

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Bibliographic Details
Published in:The American journal of cardiology 2009-03, Vol.103 (6), p.887-890
Main Authors: Charbit, Beny, MD, Christin-Maître, Sophie, MD, PhD, Démolis, Jean-Louis, MD, PhD, Soustre, Elsa, PharmD, Young, Jacques, MD, PhD, Funck-Brentano, Christian, MD, PhD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular Agents - administration & dosage
Cardiovascular Agents - blood
Electrocardiography - drug effects
Exercise Test
Heart rate
Humans
Hypogonadism - blood
Hypogonadism - drug therapy
Male
Medical sciences
Mens health
Middle Aged
Pharmacology
Studies
Testosterone
Testosterone - administration & dosage
Testosterone - blood
Ventricular Function - drug effects
Ventricular Function - physiology
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Summary:QT-interval duration is shorter in men than in women. Estrogens do not significantly influence the duration of repolarization. The effect of testosterone has not been studied directly in humans. The aim of this study was to assess the effects of testosterone on corrected QT duration in hypogonadic men. Eleven hypogonadic men were enrolled in this prospective interventional study. Digital electrocardiograms were recorded for each participant at 3 levels of testosterone, high, medium, and low, after a single intramuscular administration of testosterone. Heart rate–independent assessment of QT-interval duration was used. QT1,000 (QT at 60 beats/min) was determined for each subject. Total blood testosterone and the ratio of testosterone to sex hormone–binding globulin were assessed at each visit. The median values of QT1,000 were 352 ms (interquartile range 340 to 363), 357 ms (interquartile range 349 to 367), and 363 ms (interquartile range 357 to 384) at high, medium, and low testosterone concentrations, respectively (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2008.11.041