Novel Mannich ketones of oxazolidinones as antibacterial agents

A few Mannich ketones of piperazinyl oxazolidinone derivatives have been synthesized and their antibacterial activity in various Gram-positive organisms such as Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis were evaluated by MIC determination. Compoun...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2004-11, Vol.39 (11), p.989-992
Main Authors: Srivastava, Brijesh Kumar, Kapadnis, Prashant B., Pandya, Purvi, Lohray, Vidya Bhushan
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacillus subtilis - drug effects
Biological and medical sciences
Enterococcus faecalis - drug effects
Eperezolid
Gram-positive organism
In-vitro MIC
Ketones - chemical synthesis
Ketones - chemistry
Ketones - pharmacology
Linezolid
Mannich ketones
Medical sciences
Microbial Sensitivity Tests
Oxazolidinone
Oxazolidinones - chemical synthesis
Oxazolidinones - chemistry
Oxazolidinones - pharmacology
Pharmacology. Drug treatments
Piperazines - chemical synthesis
Piperazines - chemistry
Piperazines - pharmacology
Staphylococcus aureus - drug effects
Staphylococcus epidermidis - drug effects
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Description
Summary:A few Mannich ketones of piperazinyl oxazolidinone derivatives have been synthesized and their antibacterial activity in various Gram-positive organisms such as Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis were evaluated by MIC determination. Compound 12 showed comparable activity (MIC) to linezolid and superior to eperezolid.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2004.07.007