Genetic analysis of the M RNA segment of Crimean-Congo hemorrhagic fever virus strains involved in the recent outbreaks in Russia

Crimean-Congo hemorrhagic fever (CCHF) is a severe zoonosis with a high fatality rate. In Russia, local CCHF outbreaks have occurred in the Stavropol Territory, and the Volgograd and Astrakhan Regions during 2000 and 2001. Seven strains of CCHF virus (CCHFV) were isolated from infected patients and...

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Bibliographic Details
Published in:Archives of virology 2004-11, Vol.149 (11), p.2199-2213
Main Authors: Kuhn, J.H, Seregin, S.V, Morzunov, S.P, Petrova, I.D, Vyshemirskii, O.I, Lvov, D.K, Tyunnikov, G.I, Gutorov, V.V, Netesov, S.V, Petrov, V.S
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Antigens
Arachnids
Crimean-Congo hemorrhagic fever virus
Disease Outbreaks
Epidemiology
Fatalities
Fever
Genomes
Hemorrhagic Fever Virus, Crimean-Congo - genetics
Hemorrhagic Fever, Crimean - epidemiology
Hemorrhagic Fever, Crimean - virology
Humans
Hyalomma marginatum
Infectious diseases
Molecular Sequence Data
Phylogeny
RNA polymerase
RNA, Viral - genetics
Russia
strain differences
tick-borne diseases
Virology
zoonoses
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Summary:Crimean-Congo hemorrhagic fever (CCHF) is a severe zoonosis with a high fatality rate. In Russia, local CCHF outbreaks have occurred in the Stavropol Territory, and the Volgograd and Astrakhan Regions during 2000 and 2001. Seven strains of CCHF virus (CCHFV) were isolated from infected patients and collected ticks. Two fragments of the CCHF virus M genome segment were PCR amplified and their nucleotide sequences were determined. All these virus strains appear to be closely related (up to 5.8% nucleotide sequence differences) and form a distinct clade on the CCHFV phylogenetic tree. Within this clade, CCHFV strains from Stavropol and Astrakhan cluster together, whereas those from Volgograd form a separate subgroup.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-004-0354-3