Expression of the class I interferon-related MxA protein in temporal arteries in polymyalgia rheumatica and temporal arteritis

• Published in: Scandinavian journal of rheumatology 2009-01, Vol.38 (2), p.144-148
• Main Authors: Nordborg, C., Larsson, K., Åman, P., Nordborg, E.
• Format: Article
• Language: English
• Subjects: Aged; Biological and medical sciences; Biological Markers; Biomarkers - metabolism; Biopsy; Cell and Molecular Biology; Cell- och molekylärbiologi; Connective Tissue; Connective Tissue - metabolism; Connective Tissue - pathology; Dendritic Cells; Dendritic Cells - metabolism; Dendritic Cells - pathology; Diseases of the osteoarticular system; Endothelium; Endothelium, Vascular - metabolism; Endothelium, Vascular - pathology; Female; Giant Cell Arteritis; Giant Cell Arteritis - metabolism; Giant Cell Arteritis - pathology; GTP-Binding Proteins; GTP-Binding Proteins - metabolism; Humans; Immunohistochemistry; Inflammatory joint diseases; Interferon Type I; Male; Medical sciences; metabolism; Myxovirus Resistance Proteins; pathology; Polymyalgia Rheumatica; Polymyalgia Rheumatica - metabolism; Polymyalgia Rheumatica - pathology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Temporal Arteries; Temporal Arteries - metabolism; Temporal Arteries - pathology; Vascular
• ISSN: 0300-9742; 1502-7732; 1502-7732
• DOI: 10.1080/03009740802448841

Objective: The aim of this study was to assess the expression of the interferon type I (IFN-I)-associated MxA protein in polymyalgia rheumatica (PMR) and temporal arteritis (TA). Methods: Non-inflamed temporal artery biopsies from 11 PMR patients were compared with biopsies from 13 patients given other diagnoses. Coded sections were screened immunocytochemically for MxA protein, CD83, CD68, CD3, and S100 protein. Inflamed temporal artery biopsies from four patients with TA were also investigated. Results: Focal MxA expression was seen in non-inflamed arteries, more frequently in PMR than in controls (p = 0.0124). MxA expression was also more common in adventitial dendritic cells (DCs) in PMR (p = 0.0124). Activated adventitial DCs were detected in PMR. Focal MxA expression in the inflamed biopsies from the patients with TA was not related spatially to the inflammation. Conclusions: The expression of MxA protein in arteries from patients with PMR and TA shows that non-inflamed and inflamed vessel walls are influenced by IFN-I. Further studies are required to elucidate whether IFN-I plays a role in the initiation of PMR and or TA, serving as a link between the innate and the adaptive immune responses, as in some other autoimmune disorders.