Polymorphism of renin-angiotensin system genes in IgA nephropathy

Background and Aims:  Individuals are prone to disease because of certain disease‐susceptible genes. The angiotensin I‐converting enzyme (ACE) gene insertion/deletion (I/D), the angiotensinogen (AGT) gene, M235T, and the angiotensin II type 1 receptor (ATR) gene, A1166C, polymorphisms have been asso...

Full description

Saved in:
Bibliographic Details
Published in:Nephrology (Carlton, Vic.) Vic.), 2004-10, Vol.9 (5), p.304-309
Main Authors: WOO, KENG-THYE, LAU, YEOW-KOK, CHOONG, LINA HL, ZHAO, YI, TAN, HWEE-BOON, FOOK-CHONG, STEPHANIE, TAN, ENG-KING, YAP, HUI-KIM, WONG, KOK-SENG
Format: Article
Language:English
Subjects:
Adult
China
end-stage renal failure
Female
genetic markers
Genetic Predisposition to Disease
Genotype
Glomerulonephritis, IGA - complications
Glomerulonephritis, IGA - genetics
Humans
Kidney Failure, Chronic - genetics
Male
Middle Aged
Polymorphism, Genetic
renin-angiotensin system
Renin-Angiotensin System - genetics
risk factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Aims:  Individuals are prone to disease because of certain disease‐susceptible genes. The angiotensin I‐converting enzyme (ACE) gene insertion/deletion (I/D), the angiotensinogen (AGT) gene, M235T, and the angiotensin II type 1 receptor (ATR) gene, A1166C, polymorphisms have been associated with IgA nephropathy (IgAN) and its progression. Several studies on Caucasians and Japanese patients have reported contradictory results. We determined these polymorphisms in 118 Chinese patients with IgAN and 94 healthy Chinese subjects to assess their clinical impact. Methods:  Genotyping was performed with DNA isolated from peripheral leucocytes, polymerase chain reaction amplification of the polymorphic sequence, restriction enzymes digestion, and separation and identification of DNA fragments. Clinical data at renal biopsy and final status on renal function were determined from patients’ records. Results:  Comparing all IgAN patients with controls, AGT and ATR genotype distributions were similar, whereas there was a significant increase in the ACE DD genotype (P 
ISSN:1320-5358
1440-1797
DOI:10.1111/j.1440-1797.2004.00291.x