Diuretic effect of the aqueous extract of Bidens odorata in the rat

• Published in: Journal of ethnopharmacology 2004-12, Vol.95 (2), p.363-366
• Main Authors: Meléndez Camargo, Ma. Estela, Berdeja, Blanca, Miranda, Guadalupe
• Format: Article
• Language: English
• Subjects: acute toxicity; aerial parts; Animals; Bidens; Bidens odorata; bioactive properties; Biological and medical sciences; Compositae; diuretic activity; Diuretics - isolation & purification; Diuretics - pharmacology; Female; General pharmacology; Medical sciences; medicinal plants; Medicine, Traditional; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Components, Aerial; plant extracts; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Rats; Rats, Wistar; Saluretic effect; traditional medicine; Urination - drug effects; Urination - physiology; Water - pharmacology; Water excretion; Water-Electrolyte Balance - drug effects; Water-Electrolyte Balance - physiology
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2004.08.005

The aerial part of Bidens odorata Cav., are used in Mexican Folk Medicine to treat renal diseases. The aim of this study is to measure the diuretic response to aqueous extract of this plant at doses of 41 and 166 mg/kg and to compare it with that induced by furosemide at 2 mg/kg. Aqueous extracts, furosemide or vehicle were administered orally to adult rats and the effects on sodium, potassium and water balance were assessed. Aqueous extracts at both doses and furosemide produced important and significant increments in urinary excretion of sodium, potassium and water in rats with respect to control group. This increase was dose dependent and aqueous extract at the highest dose induced a more marked sodium and water excretion than furosemide, potassium excretion increased but it was less than the one induced by furosemide. These results suggest that the aqueous extract of Bidens odorata induce diuretic response.