Cytokeratin Positivity in Paraffin-embedded Malignant Melanomas: Comparative Study of KL1, A4 and Lu5 Antibodies

The unclear role of cytokeratin (CK) in the progression and diagnostics of malignant melanomas stimulated us to compare the reactivity of three antibodies directed to CK in 109 paraffin-embedded melanomas. By far the majority of melanomas did not express cytokeratin even at the

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Bibliographic Details
Published in:Anticancer research 2004-09, Vol.24 (5B), p.3203-3207
Main Authors: KORABIOWSKA, Monika, FISCHER, Gösta, STEINACKER, Anja, STACHURA, Jerzy, CORDON-CARDO, Carlos, BRINCK, Ulrich
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal - chemistry
Antibodies, Monoclonal - immunology
Antibody Specificity
Biological and medical sciences
Dermatology
Female
Humans
Immunohistochemistry
Keratins - biosynthesis
Keratins - immunology
Male
Medical sciences
Melanoma - metabolism
Melanoma - pathology
Middle Aged
Neoplasm Staging
Paraffin Embedding
Prognosis
Tumors
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:The unclear role of cytokeratin (CK) in the progression and diagnostics of malignant melanomas stimulated us to compare the reactivity of three antibodies directed to CK in 109 paraffin-embedded melanomas. By far the majority of melanomas did not express cytokeratin even at the
ISSN:0250-7005
1791-7530