A clinical trial demonstrates the analgesic activity of intravenous parecoxib sodium compared with ketorolac or morphine after gynecologic surgery with laparotomy

The purpose of this study was to compare the analgesic activity of 2 doses of parecoxib sodium, ketorolac, and morphine with placebo after gynecologic surgery that requires laparotomy. In a randomized, controlled, double-blind, parallel-group study, 208 patients, after surgical hysterectomy, receive...

Full description

Saved in:
Bibliographic Details
Published in:American journal of obstetrics and gynecology 2004-10, Vol.191 (4), p.1183-1191
Main Authors: Bikhazi, George B., Snabes, Michael C., Bajwa, Zahid H., Davis, Derek J., LeComte, Diane, Traylor, Louise, Hubbard, Richard C.
Format: Article
Language:English
Subjects:
Adult
Aged
Analgesics - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Biological and medical sciences
Double-Blind Method
Female
Gynecologic Surgical Procedures
Gynecology. Andrology. Obstetrics
Humans
Hysterectomy
Isoxazoles - administration & dosage
Isoxazoles - therapeutic use
Ketorolac - administration & dosage
Ketorolac - therapeutic use
Laparotomy
Laparotomy surgery
Medical sciences
Middle Aged
Morphine - therapeutic use
Pain Measurement
Pain, Postoperative - prevention & control
Parecoxib sodium
Postoperative pain
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The purpose of this study was to compare the analgesic activity of 2 doses of parecoxib sodium, ketorolac, and morphine with placebo after gynecologic surgery that requires laparotomy. In a randomized, controlled, double-blind, parallel-group study, 208 patients, after surgical hysterectomy, received single-dose intravenous placebo, parecoxib sodium 20 mg or 40 mg, ketorolac 30 mg, or morphine 4 mg followed by multiple-dose parecoxib sodium or ketorolac as needed. Primary efficacy variables were time to onset of analgesia, pain intensity differences, pain relief, time to first rescue/remedication, and global evaluation of study medication. Single-dose parecoxib sodium 40 mg provided significantly better pain responses to placebo or morphine 4 mg and was comparable to ketorolac 30 mg. Multiple-dose parecoxib sodium 20 mg, 4 times daily, or 40 mg, twice daily, was comparable to ketorolac 30 mg, 4 times daily. Parecoxib sodium was well tolerated. Parecoxib sodium is an effective analgesic in the management of acute postoperative pain after laparotomy surgery.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2004.05.006