Modulation of the primary and the secondary antibody response by tobacco smoke condensates

Cigarette smoke condensate administered to C57BL/6 mice led to a decrease in the primary antibody response to OVA (hen egg albumin) antigen. Selenium (Se)-supplementation allowed to relieve significantly this inhibition. Moreover, even being not supplemented with Se, a preparation was found devoid o...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2004-11, Vol.58 (9), p.527-530
Main Authors: Nguyen Van Binh, Pascale, Zhou, Dong, Baudouin, Françoise, Martin, Chantal, Radionoff, Martine, Dutertre, Hélène, Marchand, Véronique, Thevenin, Marc, Warnet, Jean-Michel, Duc, Huynh Thien
Format: Article
Language:English
Subjects:
Antibody response
Cigarette smoke condensates
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Summary:Cigarette smoke condensate administered to C57BL/6 mice led to a decrease in the primary antibody response to OVA (hen egg albumin) antigen. Selenium (Se)-supplementation allowed to relieve significantly this inhibition. Moreover, even being not supplemented with Se, a preparation was found devoid of inhibitory effects. Furthermore, the presence of Se-supplemented tobacco smoke condensate at the time of antigen priming, contributed to an enhanced secondary antibody response.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2004.08.021