Serum Ferritin Levels Predict All-Cause and Infection-Cause 1-Year Mortality in Diabetic Patients on Maintenance Hemodialysis

The aim of this study was to assess the relationship between the serum ferritin level and the 1-year outcome in diabetic maintenance hemodialysis (MHD) patients. The prospective clinical study enrolled 187 diabetic MHD patients from a university hospital in Taiwan. All the patients were divided into...

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Bibliographic Details
Published in:The American journal of the medical sciences 2009-03, Vol.337 (3), p.188-194
Main Authors: Jenq, Chang-Chyi, Hsu, Ching-Wei, Huang, Wen-Hung, Chen, Kuan-Hsing, Lin, Ja-Liang, Lin-Tan, Dan-Tzu
Format: Article
Language:English
Subjects:
Biological and medical sciences
Creatinine - blood
Diabetes mellitus
Diabetic Nephropathies - blood
Diabetic Nephropathies - mortality
Diabetic Nephropathies - therapy
Epidemiology
Female
Ferritin
Ferritins - blood
General aspects
Hemodialysis
Humans
Infection - mortality
Iron supply
Male
Medical sciences
Middle Aged
Mortality
Proportional Hazards Models
Prospective Studies
Public health. Hygiene
Public health. Hygiene-occupational medicine
Renal Dialysis - mortality
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Summary:The aim of this study was to assess the relationship between the serum ferritin level and the 1-year outcome in diabetic maintenance hemodialysis (MHD) patients. The prospective clinical study enrolled 187 diabetic MHD patients from a university hospital in Taiwan. All the patients were divided into 3 groups according to their serum ferritin levels: group I (700 ng/mL; n=19). A total of 26 demographic, clinical, and laboratory variables were analyzed as predictors of the 1-year mortality. There were no significant differences between these 3 groups except in their erythropoietin usage, hemoglobin, transferrin saturation, and high-sensitive C-reactive protein levels. The 1-year mortality rates were 9.2%, 11.4%, and 46.2% in groups I, II, and III, respectively. Group I and group II patients had a lower 1-year mortality rate than group III patients (log-rank test; χ2=8.807; P=0.0112). The study suggested that serum ferritin levels predict both all-cause and infection-cause 1-year mortality in diabetic patients on MHD. In such patients, the serum ferritin levels are associated with both iron stores and the inflammation status.
ISSN:0002-9629
1538-2990
DOI:10.1097/MAJ.0b013e31818d8bbe