Studies in Otitis Media: Children's Hospital Of Pittsburgh-University of Pittsburgh Progress Report-2004

Objectives/Hypothesis: The present Progress Report has summarized the key otitis media clinical trials and laboratory studies conducted since 1969 by investigators at the Children's Hospital of Pittsburgh–University of Pittsburgh (Pittsburgh, PA). Study Design: Review. Methods: Included in the...

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Bibliographic Details
Published in:The Laryngoscope 2004-11, Vol.114 (S105), p.1-26
Main Author: Bluestone, Charles D.
Format: Article
Language:English
Subjects:
Adenoidectomy
anatomy
Animals
Anti-Bacterial Agents - therapeutic use
Biological and medical sciences
Child
Child, Preschool
Clinical Trials as Topic
Disease Models, Animal
Ear, Middle - pathology
Ear, Middle - physiopathology
epidemiology
Eustachian Tube - pathology
Eustachian Tube - physiopathology
Histamine Antagonists - therapeutic use
Humans
Infant
management
Medical sciences
Middle Ear Ventilation
Myringoplasty
Nasal Decongestants - therapeutic use
Otitis media
Otitis Media - epidemiology
Otitis Media - etiology
Otitis Media - pathology
Otitis Media - physiopathology
Otitis Media - therapy
Otitis Media with Effusion - diagnosis
Otorhinolaryngology. Stomatology
pathogenesis
physiology
Risk Factors
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Summary:Objectives/Hypothesis: The present Progress Report has summarized the key otitis media clinical trials and laboratory studies conducted since 1969 by investigators at the Children's Hospital of Pittsburgh–University of Pittsburgh (Pittsburgh, PA). Study Design: Review. Methods: Included in the discussion are the following: 1) studies of the epidemiology and risk factors; 2) anatomy and pathology of the eustachian tube–middle ear from human temporal bone histopathological specimens; 3) physiology and pathophysiology of the eustachian tube–middle ear in humans and animal models; 4) pathogenesis; 5) otitis media in special populations (e.g., patients with cleft palate, Native Americans, patients with Down syndrome); 6) microbiology; 7) diagnosis; 8) outcomes of randomized clinical trials that evaluated efficacy of nonsurgical and surgical methods of treatment and prevention; 9) studies of certain complications and sequelae (e.g., effect of middle‐ear effusion on hearing, early child development, and the vestibular system; chronic suppurative otitis media). Also included are relevant summary tables and 256 references.
ISSN:0023-852X
1531-4995
DOI:10.1097/01.mlg.0000148223.45374.ec