Dynamic kinetic resolution of beta-keto sulfones via asymmetric transfer hydrogenation

The dynamic kinetic resolution of beta-keto sulfones was achieved via asymmetric transfer hydrogenation using (S,S)-RuCl[N-(tosyl)-1,2-diphenylethylenediamine](p-cymene) in the presence of formic acid and triethylamine afforded the desired products in good yield with up to >99 : 1 dr and high ee...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2009-02 (5), p.571-573
Main Authors: Ding, Zhenhua, Yang, Jin, Wang, Ting, Shen, Zongxuan, Zhang, Yawen
Format: Article
Language:English
Online Access:Get full text
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Summary:The dynamic kinetic resolution of beta-keto sulfones was achieved via asymmetric transfer hydrogenation using (S,S)-RuCl[N-(tosyl)-1,2-diphenylethylenediamine](p-cymene) in the presence of formic acid and triethylamine afforded the desired products in good yield with up to >99 : 1 dr and high ee up to >99%.
ISSN:1359-7345
DOI:10.1039/b818257d