Novel web-based tools combining chemistry informatics, biology and social networks for drug discovery

A convergence of different commercial and publicly accessible chemical informatics, databases and social networking tools is positioned to change the way that research collaborations are initiated, maintained and expanded, particularly in the realm of neglected diseases. A community-based platform t...

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Bibliographic Details
Published in:Drug discovery today 2009-03, Vol.14 (5), p.261-270
Main Authors: Hohman, Moses, Gregory, Kellan, Chibale, Kelly, Smith, Peter J., Ekins, Sean, Bunin, Barry
Format: Article
Language:English
Subjects:
Antimalarials - pharmacology
Biological and medical sciences
Cooperative Behavior
Databases, Factual
Drug Discovery
General pharmacology
Humans
Information Services
Intellectual Property
Internet
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Social Support
Software
Systems Biology - methods
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Summary:A convergence of different commercial and publicly accessible chemical informatics, databases and social networking tools is positioned to change the way that research collaborations are initiated, maintained and expanded, particularly in the realm of neglected diseases. A community-based platform that combines traditional drug discovery informatics with Web2.0 features in secure groups is believed to be the key to facilitating richer, instantaneous collaborations involving sensitive drug discovery data and intellectual property. Heterogeneous chemical and biological data from low-throughput or high-throughput experiments are archived, mined and then selectively shared either just securely between specifically designated colleagues or openly on the Internet in standardized formats. We will illustrate several case studies for anti-malarial research enabled by this platform, which we suggest could be easily expanded more broadly for pharmaceutical research in general.
ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2008.11.015