Rapidly Rising Prevalence of Nosocomial Multidrug‐Resistant, Gram‐Negative Bacilli: A 9‐Year Surveillance Study

To examine and quantify the temporal trends of nosocomial multidrug-resistant, gram-negative bacilli. A 9-year surveillance study was conducted. Multidrug resistance was defined as resistance to 3 or more antimicrobial classes. Tertiary-care institution. From 1994 to 2002, multidrug-resistant, gram-...

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Bibliographic Details
Published in:Infection control and hospital epidemiology 2004-10, Vol.25 (10), p.842-846
Main Author: D’Agata, Erika M. C.
Format: Article
Language:English
Subjects:
Aminoglycosides
Antibiotics
Antimicrobials
Biological and medical sciences
Cross Infection - epidemiology
Drug Resistance, Multiple, Bacterial
E coli
Enterobacter
Enterobacteriaceae Infections - epidemiology
Escherichia coli
Escherichia coli Infections - epidemiology
Gram-Negative Bacterial Infections - epidemiology
Infections
Klebsiella
Klebsiella Infections - epidemiology
Medical sciences
Miscellaneous
Multiple drug resistance
Nosocomial infection
Nursing
Original Articles
Pathogens
Prevalence
Proteus Infections - epidemiology
Pseudomonas aeruginosa
Pseudomonas Infections - epidemiology
Public health. Hygiene
Public health. Hygiene-occupational medicine
Quinolones
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Summary:To examine and quantify the temporal trends of nosocomial multidrug-resistant, gram-negative bacilli. A 9-year surveillance study was conducted. Multidrug resistance was defined as resistance to 3 or more antimicrobial classes. Tertiary-care institution. From 1994 to 2002, multidrug-resistant, gram-negative bacilli increased from 1% to 16% for multidrug-resistant Pseudomonas aeruginosa, 4% to 13% for multidrug-resistant Enterobacter species, 0.5% to 17% for multidrug-resistant Klebsiella species, 0% to 9% for multidrug-resistant Proteus species, and 0.2% to 4% for multidrug-resistant Escherichia coli (P < or = .05). The most common pattern of multidrug resistance was co-resistance to quinolones, third-generation cephalosporins, and aminoglycosides. The rapid rise of multidrug-resistant, gram-negative bacilli may warrant infection control programs to include these pathogens in strategies aimed at limiting the emergence and spread of antimicrobial-resistant pathogens.
ISSN:0899-823X
1559-6834
DOI:10.1086/502306