Taurolidine is effective in the treatment of central venous catheter-related bloodstream infections in cancer patients

Taurolidine is an antimicrobial agent that was originally used in the local treatment of peritonitis and was shown to be effective in the prevention of catheter-related bloodstream infections (CR-BSI). In this pilot study, we used taurolidine solution as an intravenous (i.v.) lock into the totally i...

Full description

Saved in:
Bibliographic Details
Published in:International journal of antimicrobial agents 2004-11, Vol.24 (5), p.491-495
Main Authors: Koldehoff, M., Zakrzewski, J.L.
Format: Article
Language:English
Subjects:
Adult
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial lock solution
Bacteremia - drug therapy
Bacteremia - etiology
Bacteremia - prevention & control
Biological and medical sciences
Bloodstream infections
Catheterization, Central Venous - adverse effects
Female
Humans
Male
Medical sciences
Neoplasms - complications
Pharmacology. Drug treatments
Pilot Projects
Prosthesis-Related Infections - drug therapy
Solutions
Taurine - administration & dosage
Taurine - analogs & derivatives
Taurine - therapeutic use
Taurolidine
Thiadiazines - therapeutic use
Totally implantable intravascular devices
Treatment
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Taurolidine is an antimicrobial agent that was originally used in the local treatment of peritonitis and was shown to be effective in the prevention of catheter-related bloodstream infections (CR-BSI). In this pilot study, we used taurolidine solution as an intravenous (i.v.) lock into the totally implantable intravascular devices of 11 consecutive oncological patients with catheter-related bloodstream infections not responding to systemic antimicrobial chemotherapy. All patients recovered completely from the infection. No adverse drug effects were seen. Three patients were successfully retreated for a recurrent infection. Our data suggest a beneficial role of taurolidine i.v. lock for the therapy of catheter-related bloodstream infections in oncological patients. Taurolidine i.v. lock application is feasible and could especially be useful in infections resistant to antibiotic chemotherapy.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2004.06.006