Case of cutaneous Scedosporium apiospermum infection successfully treated with voriconazole

ABSTRACT We report a case of cutaneous infection due to Scedosporium apiospermum in a 75‐year‐old immunocompromised male patient who had received long‐term corticosteroid and immunosuppressant therapy for the treatment of nephrotic syndrome. The patient came to our department complaining of erythema...

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Bibliographic Details
Published in:Journal of dermatology 2009-02, Vol.36 (2), p.98-102
Main Authors: MATSUMOTO, Yuka, OH‐I, Tsunao, NAGAI, Ayako, OHYAMA, Fuminori, OOISHI, Tsuyoshi, TSUBOI, Ryoji
Format: Article
Language:English
Subjects:
Antifungal Agents - therapeutic use
Humans
hyalohyphomycosis
Immunocompromised Host
Immunosuppressive Agents - adverse effects
Male
Mycetoma - drug therapy
Mycetoma - immunology
Mycetoma - microbiology
Nephrotic Syndrome - drug therapy
Pyrimidines - therapeutic use
Scedosporium
Scedosporium - isolation & purification
Scedosporium apiospermum
Scedosporium infection
Triazoles - therapeutic use
Voriconazole
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Summary:ABSTRACT We report a case of cutaneous infection due to Scedosporium apiospermum in a 75‐year‐old immunocompromised male patient who had received long‐term corticosteroid and immunosuppressant therapy for the treatment of nephrotic syndrome. The patient came to our department complaining of erythema with a number of pustules on the dorsal surface of the right hand. S. apiospermum was identified from a culture taken from the pus. After unsuccessful treatment with topical ketoconazole, oral itraconazole and oral terbinafine, the lesion quickly resolved with the daily administration of 400 mg voriconazole. No recurrence was observed despite discontinuation of voriconazole due to drug‐induced hepatitis. Voriconazole holds out the promise of an effective treatment for invasive Scedosporium infection.
ISSN:0385-2407
1346-8138
DOI:10.1111/j.1346-8138.2009.00597.x