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Synthesis and Cytotoxicity Screening of Piperazine-1-carbodithioate Derivatives of 2-Substituted Quinazolin-4(3H)-ones

A new series of piperazine‐1‐carbodithioate derivatives of 2‐substituted quinazolin‐4(3H)‐ones were synthesized via a five‐steps procedure starting from 2‐amino‐5‐methylbenzoic acid. The cytotoxicity of the resulting compounds against A‐549 (human lung cancer), HCT‐8 (human colon cancer), HepG2 (hum...

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Published in:	Archiv der Pharmazie (Weinheim) 2009-03, Vol.342 (3), p.182-189
Main Authors:	Cao, Sheng-Li, Guo, Yan-Wen, Wang, Xian-Bo, Zhang, Mei, Feng, Yu-Ping, Jiang, Yu-Yang, Wang, Yue, Gao, Qian, Ren, Jian
Format:	Article
Language:	English
Subjects:	Antineoplastic Agents - chemistry Cell Line, Tumor Cell Survival - drug effects Cytotoxicity Dithiocarbamate Drug Screening Assays, Antitumor Humans Quinazolin-4(3H)-one Quinazolinones - chemical synthesis Quinazolinones - pharmacology Screening Synthesis
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creator	Cao, Sheng-Li Guo, Yan-Wen Wang, Xian-Bo Zhang, Mei Feng, Yu-Ping Jiang, Yu-Yang Wang, Yue Gao, Qian Ren, Jian
description	A new series of piperazine‐1‐carbodithioate derivatives of 2‐substituted quinazolin‐4(3H)‐ones were synthesized via a five‐steps procedure starting from 2‐amino‐5‐methylbenzoic acid. The cytotoxicity of the resulting compounds against A‐549 (human lung cancer), HCT‐8 (human colon cancer), HepG2 (human liver cancer), and K562 (human myelogenous leukaemia) cell lines was determined by the MTT assay. Preliminary screening results of these compounds are reported.
doi_str_mv	10.1002/ardp.200800148
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subjects	Antineoplastic Agents - chemistry Cell Line, Tumor Cell Survival - drug effects Cytotoxicity Dithiocarbamate Drug Screening Assays, Antitumor Humans Quinazolin-4(3H)-one Quinazolinones - chemical synthesis Quinazolinones - pharmacology Screening Synthesis
title	Synthesis and Cytotoxicity Screening of Piperazine-1-carbodithioate Derivatives of 2-Substituted Quinazolin-4(3H)-ones
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