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Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells
Induced pluripotent stem (iPS) cells were recently established from human fibroblasts. In the present study we investigated the adipogenic differentiation properties of four human iPS cell lines and compared them with those of two human embryonic stem (ES) cell lines. After 12 days of embryoid body...
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| Published in: | FEBS letters 2009-03, Vol.583 (6), p.1029-1033 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c5064-3cd69bb756fa583c1335afa2c707a94d8d1a55d127ae9ed0cf431f952a437d523 |
| container_end_page | 1033 |
| container_issue | 6 |
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| container_title | FEBS letters |
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| creator | Taura, Daisuke Noguchi, Michio Sone, Masakatsu Hosoda, Kiminori Mori, Eisaku Okada, Yohei Takahashi, Kazutoshi Homma, Koichiro Oyamada, Naofumi Inuzuka, Megumi Sonoyama, Takuhiro Ebihara, Ken Tamura, Naohisa Itoh, Hiroshi Suemori, Hirofumi Nakatsuji, Norio Okano, Hideyuki Yamanaka, Shinya Nakao, Kazuwa |
| description | Induced pluripotent stem (iPS) cells were recently established from human fibroblasts. In the present study we investigated the adipogenic differentiation properties of four human iPS cell lines and compared them with those of two human embryonic stem (ES) cell lines. After 12
days of embryoid body formation and an additional 10
days of differentiation on Poly-
l-ornithine and fibronectin- coated dishes with adipogenic differentiation medium, human iPS cells exhibited lipid accumulation and transcription of adipogenesis-related molecules such as C/EBPα, PPARγ2, leptin and aP2. These results demonstrate that human iPS cells have an adipogenic potential comparable to human ES cells. |
| doi_str_mv | 10.1016/j.febslet.2009.02.031 |
| format | article |
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days of embryoid body formation and an additional 10
days of differentiation on Poly-
l-ornithine and fibronectin- coated dishes with adipogenic differentiation medium, human iPS cells exhibited lipid accumulation and transcription of adipogenesis-related molecules such as C/EBPα, PPARγ2, leptin and aP2. These results demonstrate that human iPS cells have an adipogenic potential comparable to human ES cells.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2009.02.031</identifier><identifier>PMID: 19250937</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adipocyte ; Adipocytes - drug effects ; Adipocytes - physiology ; Adipogenesis ; Adipogenesis - drug effects ; Adipogenesis - genetics ; Adipogenesis - physiology ; Biomarkers - metabolism ; CCAAT-Enhancer-Binding Proteins - genetics ; CCAAT-Enhancer-Binding Proteins - metabolism ; Cell Culture Techniques ; Cell Differentiation - drug effects ; Cell Differentiation - genetics ; Cell Differentiation - physiology ; Cells, Cultured ; Differentiation ; Embryonic Stem Cells - drug effects ; Embryonic Stem Cells - metabolism ; Embryonic Stem Cells - physiology ; Fatty Acid-Binding Proteins - genetics ; Fatty Acid-Binding Proteins - metabolism ; Fibronectins - pharmacology ; Gene Expression ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; Humans ; Leptin - genetics ; Leptin - metabolism ; Nanog Homeobox Protein ; Peptides - pharmacology ; Pluripotent Stem Cells - drug effects ; Pluripotent Stem Cells - metabolism ; Pluripotent Stem Cells - physiology ; PPAR gamma - genetics ; PPAR gamma - metabolism ; Stem cell</subject><ispartof>FEBS letters, 2009-03, Vol.583 (6), p.1029-1033</ispartof><rights>2009 Federation of European Biochemical Societies</rights><rights>FEBS Letters 583 (2009) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5064-3cd69bb756fa583c1335afa2c707a94d8d1a55d127ae9ed0cf431f952a437d523</citedby><cites>FETCH-LOGICAL-c5064-3cd69bb756fa583c1335afa2c707a94d8d1a55d127ae9ed0cf431f952a437d523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579309001434$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3536,27905,27906,45761</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19250937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taura, Daisuke</creatorcontrib><creatorcontrib>Noguchi, Michio</creatorcontrib><creatorcontrib>Sone, Masakatsu</creatorcontrib><creatorcontrib>Hosoda, Kiminori</creatorcontrib><creatorcontrib>Mori, Eisaku</creatorcontrib><creatorcontrib>Okada, Yohei</creatorcontrib><creatorcontrib>Takahashi, Kazutoshi</creatorcontrib><creatorcontrib>Homma, Koichiro</creatorcontrib><creatorcontrib>Oyamada, Naofumi</creatorcontrib><creatorcontrib>Inuzuka, Megumi</creatorcontrib><creatorcontrib>Sonoyama, Takuhiro</creatorcontrib><creatorcontrib>Ebihara, Ken</creatorcontrib><creatorcontrib>Tamura, Naohisa</creatorcontrib><creatorcontrib>Itoh, Hiroshi</creatorcontrib><creatorcontrib>Suemori, Hirofumi</creatorcontrib><creatorcontrib>Nakatsuji, Norio</creatorcontrib><creatorcontrib>Okano, Hideyuki</creatorcontrib><creatorcontrib>Yamanaka, Shinya</creatorcontrib><creatorcontrib>Nakao, Kazuwa</creatorcontrib><title>Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Induced pluripotent stem (iPS) cells were recently established from human fibroblasts. In the present study we investigated the adipogenic differentiation properties of four human iPS cell lines and compared them with those of two human embryonic stem (ES) cell lines. After 12
days of embryoid body formation and an additional 10
days of differentiation on Poly-
l-ornithine and fibronectin- coated dishes with adipogenic differentiation medium, human iPS cells exhibited lipid accumulation and transcription of adipogenesis-related molecules such as C/EBPα, PPARγ2, leptin and aP2. These results demonstrate that human iPS cells have an adipogenic potential comparable to human ES cells.</description><subject>Adipocyte</subject><subject>Adipocytes - drug effects</subject><subject>Adipocytes - physiology</subject><subject>Adipogenesis</subject><subject>Adipogenesis - drug effects</subject><subject>Adipogenesis - genetics</subject><subject>Adipogenesis - physiology</subject><subject>Biomarkers - metabolism</subject><subject>CCAAT-Enhancer-Binding Proteins - genetics</subject><subject>CCAAT-Enhancer-Binding Proteins - metabolism</subject><subject>Cell Culture Techniques</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - genetics</subject><subject>Cell Differentiation - physiology</subject><subject>Cells, Cultured</subject><subject>Differentiation</subject><subject>Embryonic Stem Cells - drug effects</subject><subject>Embryonic Stem Cells - metabolism</subject><subject>Embryonic Stem Cells - physiology</subject><subject>Fatty Acid-Binding Proteins - genetics</subject><subject>Fatty Acid-Binding Proteins - metabolism</subject><subject>Fibronectins - pharmacology</subject><subject>Gene Expression</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Humans</subject><subject>Leptin - genetics</subject><subject>Leptin - metabolism</subject><subject>Nanog Homeobox Protein</subject><subject>Peptides - pharmacology</subject><subject>Pluripotent Stem Cells - drug effects</subject><subject>Pluripotent Stem Cells - metabolism</subject><subject>Pluripotent Stem Cells - physiology</subject><subject>PPAR gamma - genetics</subject><subject>PPAR gamma - metabolism</subject><subject>Stem cell</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAURi0EokPhEUBZsUu4tuMkZoPKqKVIlVgAa8uxrxmP8jPYTqt5exzNSLMsK9vS-b575UPIewoVBdp82lcO-zhgqhiArIBVwOkLsqFdy0teN91LsgGgdSlaya_Imxj3kN8dla_JFZVMgOTthjzeWH-Y_-DkTWG9cxhwSl4nP0_F7IrdMuqp8JNdDNriMCwh0ykjRUw4FgaHIX4utvN40MHHnHnyaVeknU6XNI59OM7rgEvmLXnl9BDx3fm8Jr_vbn9t78uHH9--b28eSiOgqUtubCP7vhWN06LjhnIutNPMtNBqWdvOUi2EpazVKNGCcTWnTgqma95awfg1-XjqPYT574IxqdHHdQM94bxE1bTApKibZ0EGdZ4CIoPiBJowxxjQqUPwow5HRUGtZtRenc2o1YwCprKZnPtwHrD0I9pL6qwiA_cn4MkPePy_VnV3-5X9XDWvlkGuN17nqi-nKsxf--gxqGg8TlmhD2iSsrN_Ztt_vdG5bg</recordid><startdate>20090318</startdate><enddate>20090318</enddate><creator>Taura, Daisuke</creator><creator>Noguchi, Michio</creator><creator>Sone, Masakatsu</creator><creator>Hosoda, Kiminori</creator><creator>Mori, Eisaku</creator><creator>Okada, Yohei</creator><creator>Takahashi, Kazutoshi</creator><creator>Homma, Koichiro</creator><creator>Oyamada, Naofumi</creator><creator>Inuzuka, Megumi</creator><creator>Sonoyama, Takuhiro</creator><creator>Ebihara, Ken</creator><creator>Tamura, Naohisa</creator><creator>Itoh, Hiroshi</creator><creator>Suemori, Hirofumi</creator><creator>Nakatsuji, Norio</creator><creator>Okano, Hideyuki</creator><creator>Yamanaka, Shinya</creator><creator>Nakao, Kazuwa</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20090318</creationdate><title>Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells</title><author>Taura, Daisuke ; 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In the present study we investigated the adipogenic differentiation properties of four human iPS cell lines and compared them with those of two human embryonic stem (ES) cell lines. After 12
days of embryoid body formation and an additional 10
days of differentiation on Poly-
l-ornithine and fibronectin- coated dishes with adipogenic differentiation medium, human iPS cells exhibited lipid accumulation and transcription of adipogenesis-related molecules such as C/EBPα, PPARγ2, leptin and aP2. These results demonstrate that human iPS cells have an adipogenic potential comparable to human ES cells.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>19250937</pmid><doi>10.1016/j.febslet.2009.02.031</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 2009-03, Vol.583 (6), p.1029-1033 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | ScienceDirect (Online service); Wiley-Blackwell Read & Publish Collection |
| subjects | Adipocyte Adipocytes - drug effects Adipocytes - physiology Adipogenesis Adipogenesis - drug effects Adipogenesis - genetics Adipogenesis - physiology Biomarkers - metabolism CCAAT-Enhancer-Binding Proteins - genetics CCAAT-Enhancer-Binding Proteins - metabolism Cell Culture Techniques Cell Differentiation - drug effects Cell Differentiation - genetics Cell Differentiation - physiology Cells, Cultured Differentiation Embryonic Stem Cells - drug effects Embryonic Stem Cells - metabolism Embryonic Stem Cells - physiology Fatty Acid-Binding Proteins - genetics Fatty Acid-Binding Proteins - metabolism Fibronectins - pharmacology Gene Expression Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Leptin - genetics Leptin - metabolism Nanog Homeobox Protein Peptides - pharmacology Pluripotent Stem Cells - drug effects Pluripotent Stem Cells - metabolism Pluripotent Stem Cells - physiology PPAR gamma - genetics PPAR gamma - metabolism Stem cell |
| title | Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells |
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