The advanced glycation end-product Nε-(carboxymethyl)lysine level is elevated in cerebrospinal fluid of patients with amyotrophic lateral sclerosis

Oxidative stress is involved in the aetiopathogenesis of amyotrophic lateral sclerosis (ALS), a fatal degenerative disorder. To test whether oxidative stress in ALS is increased and confined to the central nervous system, we have measured the glycoxidation product N(epsilon)-(carboxymethyl)lysine (C...

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Bibliographic Details
Published in:Neuroscience letters 2004-11, Vol.371 (2-3), p.226-229
Main Authors: KAUFMANN, E, BOEHM, B. O, SÜSSMUTH, S. D, KIENTSCH-ENGEL, R, SPERFELD, A, LUDOLPH, A. C, TUMANI, H
Format: Article
Language:English
Subjects:
Adult
Aged
Amyotrophic Lateral Sclerosis - blood
Amyotrophic Lateral Sclerosis - cerebrospinal fluid
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Fundamental and applied biological sciences. Psychology
Glycation End Products, Advanced - blood
Glycation End Products, Advanced - cerebrospinal fluid
Humans
Lysine - blood
Lysine - cerebrospinal fluid
Male
Medical sciences
Middle Aged
Neurology
Statistics, Nonparametric
Vertebrates: nervous system and sense organs
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Summary:Oxidative stress is involved in the aetiopathogenesis of amyotrophic lateral sclerosis (ALS), a fatal degenerative disorder. To test whether oxidative stress in ALS is increased and confined to the central nervous system, we have measured the glycoxidation product N(epsilon)-(carboxymethyl)lysine (CML) in serum and cerebrospinal fluid (CSF) samples by means of a novel enzyme immunoassay. Significant increases of CSF/serum ratio of CML in ALS patients (n = 25) as compared to normal controls (n = 20, p = 0.001) and to Alzheimer disease patients (n = 9, p = 0.029) suggest intrathecal production of this glycoxidation product. Measurement of CML levels may provide a novel diagnostic tool and may supplement current monitoring strategies in interventional trials.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2004.08.071