Combined effects of a dietary portfolio of plant sterols, vegetable protein, viscous fibre and almonds on LDL particle size

Studies conducted in the last 20 years have led to the identification of small dense LDL as an important risk factor for CVD. Consumption of plant sterols, soyabean proteins, viscous fibre and nuts are known to modulate the risk of CVD favourably through their cholesterol (Chol)-lowering properties,...

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Bibliographic Details
Published in:British journal of nutrition 2004-10, Vol.92 (4), p.657-663
Main Authors: Lamarche, Benoît, Desroches, Sophie, Jenkins, David J. A., Kendall, Cyril W. C., Marchie, Augustine, Faulkner, Dorothea, Vidgen, Edward, Lapsley, Karen G., Trautwein, Elke A., Parker, Tina L., Josse, Robert G., Leiter, Lawrence A., Connelly, Philip W.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Almonds
Biological and medical sciences
Cholesterol
Cholesterol, LDL - chemistry
Cholesterol, LDL - drug effects
Diet
Dietary Fiber - pharmacology
Fasting - blood
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Genotype & phenotype
Hospitals
Humans
LDL particle size
Lipids
Lipids - blood
Male
Middle Aged
Nutrition research
Particle Size
Phenotypes
Phytosterols - pharmacology
Plant Proteins, Dietary - pharmacology
Plant sterols
Proteins
Prunus
Risk factors
Risk reduction
Soyabean protein
Soybeans
Sterols
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Viscous dietary fibre
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Summary:Studies conducted in the last 20 years have led to the identification of small dense LDL as an important risk factor for CVD. Consumption of plant sterols, soyabean proteins, viscous fibre and nuts are known to modulate the risk of CVD favourably through their cholesterol (Chol)-lowering properties, both independently and more recently in combination. Nevertheless, their combined impact on the LDL particle size phenotype has never been tested. In the present study, we assessed the effect of incorporating concurrently plant sterols (1 g/4·2 MJ), soyabean protein (23 g/4·2 MJ), viscous fibre (9 g/4·2 MJ) and almonds (15 g/4·2 MJ) into a diet very low in saturated fat in twelve patients with mildly elevated plasma LDL-Chol levels. Fasting blood lipids were obtained at the start of the study and at 2-week intervals during the 4-week study. The diet-induced reduction in plasma LDL-Chol of 30·0 (SE 3·0) % (P26.0 nm−30 (SE 8) %, P
ISSN:0007-1145
1475-2662
DOI:10.1079/BJN20041241