Intracerebellar granulocytic sarcoma complicating acute myelogenous leukemia: a case report and review of the literature

Granulocytic sarcoma is a solid mass composed of premature precursors of granulocytic series cells in an extramedullary region. Intraparenchymal central nervous system localization without skull or meningeal invasion is extremely rare. Although different theories have been proposed to explain the me...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2004-11, Vol.11 (8), p.914-917
Main Authors: Suzer, Tuncer, Colakoglu, Nagihan, Cirak, Bayram, Keskin, Ali, Coskun, Erdal, Tahta, Kadir
Format: Article
Language:English
Subjects:
acute myelogenous leukemia
brain
Cerebellar Neoplasms - complications
Cerebellar Neoplasms - pathology
cerebellum
chloroma
Female
granulocytic sarcoma
Humans
Leukemia, Myeloid, Acute - complications
Leukemia, Myeloid, Acute - pathology
Middle Aged
myeloblastoma
Sarcoma, Myeloid - complications
Sarcoma, Myeloid - pathology
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Summary:Granulocytic sarcoma is a solid mass composed of premature precursors of granulocytic series cells in an extramedullary region. Intraparenchymal central nervous system localization without skull or meningeal invasion is extremely rare. Although different theories have been proposed to explain the mechanism of this unusual disorder, its exact mechanism is still unclear. Some degree of improvement can be achieved after surgery and radiotherapy but its prognosis is poor and most patients die within months. Nine cases of purely intraparenchymal granulocytic sarcomas have been reported in the literature. Here, we report the tenth case and review the current literature.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2003.12.018