Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion

Adiponectin, an adipocyte-derived protein with insulin-sensitizing, anti-diabetic and anti-atherogenic activities, is known to be induced during adipocyte differentiation. Nobiletin, a citrus polymethoxy flavonoid, was found to induce the differentiation of ST-13 preadipocytes into mature adipocytes...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2009-04, Vol.19 (7), p.2062-2064
Main Authors: KUNIMASA, Kazuhiro, KURANUKI, Sachi, IGARASHI, Yasuhiro, OIKAWA, Tsutomu, MATSUURA, Nobuyasu, IWASAKI, Nozomi, IKEDA, Megumi, ITO, Akira, SASHIDA, Yutaka, MIMAKI, Yoshihiro, YANO, Masamichi, SATO, Mayumi
Format: Article
Language:English
Subjects:
Adipocytes - drug effects
Adipocytes - metabolism
Adipocytes - pathology
Adiponectin - genetics
Adiponectin - metabolism
Animals
Biological and medical sciences
Cell Differentiation
Cell Line
Citrus
Complement Factor D - metabolism
Fatty Acid-Binding Proteins - metabolism
Flavones - chemistry
Flavones - pharmacology
Flavonoids - chemistry
Flavonoids - pharmacology
General pharmacology
Medical sciences
Mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
PPAR gamma - agonists
Up-Regulation
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Summary:Adiponectin, an adipocyte-derived protein with insulin-sensitizing, anti-diabetic and anti-atherogenic activities, is known to be induced during adipocyte differentiation. Nobiletin, a citrus polymethoxy flavonoid, was found to induce the differentiation of ST-13 preadipocytes into mature adipocytes and enhance the production of adiponectin protein at a concentration of 10 microM.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2009.02.002