Evaluation of khaya gum as a directly compressible matrix system for controlled release

• Published in: Journal of pharmacy and pharmacology 2004-11, Vol.56 (11), p.1365-1370
• Main Authors: Odeku, Oluwatoyin A., Fell, John T.
• Format: Article
• Language: English
• Subjects: Acetaminophen - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Delayed-Action Preparations; Excipients; Indomethacin - administration & dosage; Khaya; Lactose - analogs & derivatives; Meliaceae; Methylcellulose - analogs & derivatives; Oxazines; Plant Preparations; Solubility; Tablets
• ISSN: 0022-3573; 2042-7158
• DOI: 10.1211/0022357044652

Khaya gum has been evaluated as a controlled release agent in modified release matrices in comparison with hydroxypropylmethylcellulose (HPMC) using paracetamol (water soluble) and indometacin (water insoluble) as model drugs. Tablets were produced by direct compression and the in‐vitro drug release was assessed in conditions mimicking the gastrointestinal system. Khaya gum matrices provided a controlled release of paracetamol for up to 5 h. The release of paracetamol from khaya gum matrices followed time‐independent kinetics (n = 1.042) and release rates were dependent on the concentration of the drug present in the matrix. The addition of tablet excipients not only improved the mechanical properties of the tablet, but also altered the dissolution profile, except for dicalcium phosphate where the profile remained unchanged. HPMC could be used to control the drug release rates from khaya gum matrices and a combination of khaya gum and HPMC gave zero‐order time‐independent release kinetics. Indometacin exhibited a lag time in excess of 2 h, due to its insolubility at low pH, before the zero‐order release was observed. Thus khaya gum matrices could be useful in the formulation of sustained release tablets for up to 5 h and the appropriate combination of khaya gum and HPMC could be used to provide a time‐independent release for longer periods.