IL-18 and IL-18 binding protein concentrations in serum and ovarian follicular fluid do not affect in vitro fertilization outcomes in obese, overweight, and non-obese patients

Abstract Obesity causes the specific upregulation of proinflammatory cytokines and chemokines. One of these cytokines, IL-18, has a well-known association with obesity. Our aim in this study was to test the effect of serum and intrafollicular IL-18 and IL-18 binding protein (BP) levels on in vitro f...

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Bibliographic Details
Published in:Journal of reproductive immunology 2009-01, Vol.79 (2), p.211-214
Main Authors: Kilic, S, Moraloglu, O, Yuksel, B, Ozaksit, G, Tasdemir, N, Dogan, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Case-Control Studies
Embryology: invertebrates and vertebrates. Teratology
Female
Fertilization in Vitro
Follicular fluid
Follicular Fluid - metabolism
Fundamental and applied biological sciences. Psychology
Health
Humans
IL-18
IL-18 binding protein
In vitro fertilization outcome
Intercellular Signaling Peptides and Proteins - analysis
Intercellular Signaling Peptides and Proteins - blood
Interleukin-18 - analysis
Interleukin-18 - blood
Obesity
Obesity - blood
Obesity - metabolism
Obstetrics and Gynecology
Overweight - blood
Overweight - metabolism
Treatment Outcome
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Summary:Abstract Obesity causes the specific upregulation of proinflammatory cytokines and chemokines. One of these cytokines, IL-18, has a well-known association with obesity. Our aim in this study was to test the effect of serum and intrafollicular IL-18 and IL-18 binding protein (BP) levels on in vitro fertilization outcomes in obese, overweight, and non-obese patients. Serum and pooled follicular fluid levels of IL-18, IL-18BP, and the IL-18/IL-18BP ratios were evaluated in 21 non-obese (body mass index [BMI]
ISSN:0165-0378
1872-7603
DOI:10.1016/j.jri.2008.10.002